Lambert-Eaton syndrome (Lambert-Eaton myasthenic syndrome)
Which are the symptoms?
Onset usually occurs in adulthood. The main symptom is weakness, which mainly affects the proximal muscles of the extremities (thighs and buttocks, less often the shoulders), but in the future it can affect all muscles. Symptoms such as dry mouth, erectile dysfunction, and constipation (called autonomic symptoms) are also common with weakness. Electromyography and the search for antibodies against calcium channels are essential for diagnosis.
How is it diagnosed?
After the diagnosis is made, tests (in particular CT and PET-CT) should be performed to rule out the presence of a tumor; in case of a negative result, the check must be repeated periodically in the coming months.
How is it treated?
LEMS weakness responds well to 3,4-diaminopyridine treatment. If a neoplasm is found, treatment usually involves recovery. Resistant forms can respond to immunosuppressive therapy or intravenous immunoglobulins.