Medical treatment of atopic and seborrheic dermatitis

What is it?

The therapy of atopic dermatitis is based on the use of local corticosteroids, with the association of non-allergic and non-irritating emollient ointments. In case of intense itching or large extension of atopic dermatitis, short systemic cortisone cycles are possible. Cyclosporine can also be used in selected cases. Recently, in non-responsive forms, innovative biological therapies, such as Dupilomab. The therapy of seborrheic dermatitis is carried out with galenic preparations based on sulfur, topical antifungals and also corticosteroids, but only for short periods. Both seborrheic dermatitis and atopic dermatitis improve with heliotherapy.

When is this procedure indicated?

In mild atopic dermatitis, moderate inflammation and scarce extension, short cycles of local cortisone creams are sufficient, to be alternated, in order to avoid side effects, with calcinerin inhibitors (Pimecrolimus and Tacrolimus 0.1% ointment). If the dermatitis is extensive and the inflammation relevant, systemic steroid therapy or the use of systemic cyclosporine is used. In case of lack of response to the above mentioned therapies, the use of the biological drug Dupilomab is proposed, with well selected criteria. Dupilomab is a human monoclonal IgG4 antibody that binds to the IL-4 receptor and inhibits the signal transduction of IL-4 and IL-13, with reduction of the cytokine cascade of inflammation.

In seborrheic dermatitis systemic therapies are almost always contraindicated, since the pathogenesis is not allergic but psychosomatic and therefore prone to relapse. Local therapies such as anti-inflammatory non-cortisone emollients or galenic products containing sulfur and local antimicrobials are preferred.

How is it performed?

Local therapies are ointments; salves are taken orally. Biologic therapy is administered by subcutaneous injection.

Are you interested in receiving the treatment?

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