Oreste Davide Gentilini


Dr. Oreste Gentilini has been the Head of the Breast Surgery Department since 2015 and the Coordinator of the Breast Diseases Department at IRCCS Ospedale San Raffaele in Milan. In addition, he collaborates with the Casa di Cura La Madonnina Clinic.

In 1993, he graduated from the Faculty of Medicine and Surgery, and in 1999, he specialized in General Surgery, in both cases with honors. Since 2001, he has been engaged in the treatment and research of breast tumors, having completed an internship in the United States at the New York Hospital-Cornell Medical Center.

From 2000 to 2015, he worked at the European Institute of Oncology, where he was the first Deputy Head of the Senology Department. From 2014 to 2015, he was the member of the Academic Council at the same institute.

He is a Project Manager for breast and axillary lymph node preservation, including after neoadjuvant chemotherapy, and an Expert in familial/hereditary tumors and preventive procedures for “risk reduction” in women with high genetic risk. He personally performed more than 5,000 breast surgeries. He is the Coordinator and Leader of the international multicenter SOUND study in the field of axillary staging in women with early breast carcinoma.

Since 2018, he is a founding member, the member of the Board of Directors and Deputy Chairman of the EU-BREAST (EUropean Breast cancer REsearch Association of Surgical Trialists). Since 2019, he has been the member of the Board of Directors of ANISC - Italian National Association of Senological Surgeons.

Since 2012, he has been the member of the European Expert Group on Breast Carcinoma in Young and Pregnant Women. Dr. Gentilini is also the member of the Editorial Board of the European Journal of Surgical Oncology, and since 2018, he has been the Profile Editor for The Brest journal (I.F. 3,4). He is the author of over 100 international publications and guest speaker at over 100 national and international congresses.

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University of Milan

Degree in Medicine and Surgery – 1993

University of Milan

Specialization in General Surgery – 1999

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Since 2018, he has been the Profile Editor of The Brest magazine (I.F. 3,4). He is the author of over 100 international publications.

Latest publications

Sentinel node biopsy after primary systemic therapy in node positive breast cancer patients: Time trend, imaging staging power and nodal downstaging according to molecular subtype.
Eur J Surg Oncol. 2019 Jun;45(6):969-975. doi: 10.1016/j.ejso.2019.01.219. Epub 2019 Jan 31. PMID: 30744944
Di Micco R, Zuber V, Fiacco E, Carriero F, Gattuso MI, Nazzaro L, Panizza P, Gianolli L, Canevari C, Di Muzio N, Pasetti M, Sassi I, Zambetti M, Gentilini OD.
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A gap analysis of opportunities and priorities for breast surgical research.
Lancet Oncol. 2019 Jan;20(1):e1. doi: 10.1016/S1470-2045(18)30916-1. PMID:30614465
Gentilini OD, De Boniface J, Classe JM, Peintinger F, Reimer T, Reitsamer R, Rubio I, Smidt M, Kuehn T.
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Oncoplastic Breast Consortium consensus conference on nipple-sparing mastectomy.
Breast Cancer Res Treat. 2018 Dec;172(3):523-537. doi: 10.1007/s10549-018-4937-1. Epub 2018 Sep 4. Review.
Weber WP, Haug M, Kurzeder C, Bjelic-Radisic V, Koller R, Reitsamer R, Fitzal F, Biazus J, Brenelli F, Urban C, Paulinelli RR, Blohmer JU, Heil J, Hoffmann J, Matrai Z, Catanuto G, Galimberti V, Gentilini O, Barry M, Hadar T, Allweis TM, Olsha O, Cardoso MJ, Gouveia PF, Rubio IT, de Boniface J, Svensjö T, Bucher S, Dubsky P, Farhadi J, Fehr MK, Fulco I, Ganz-Blättler U, Günthert A, Harder Y, Hause
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Is Axillary Sentinel Lymph Node Biopsy Required in Patients Who Undergo Primary Breast Surgery?
Breast Care (Basel). 2018 Oct;13(5):324-330. doi: 10.1159/000491703. Epub 2018 Aug 24. Review.
Reimer T, Engel J, Schmidt M, Offersen BV, Smidt ML, Gentilini OD.
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Axillary staging for breast cancer during pregnancy: feasibility and safety of sentinel lymph node biopsy.
Breast Cancer Res Treat. 2018 Apr;168(2):551-557. doi: 10.1007/s10549-017-4611-z. Epub 2017 Dec 12. PMID:29235045
Han SN, Amant F, Cardonick EH, Loibl S, Peccatori FA, Gheysens O, Sangalli CA, Nekljudova V, Steffensen KD, Mhallem Gziri M, Schröder CP, Lok CAR, Verest A, Neven P, Smeets A, Pruneri G, Cremonesi M, Gentilini O; International Network on Cancer, Infertility and Pregnancy.
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Sentinel node biopsy in early breast cancer. A review on recent and ongoing randomized trials.
Breast. 2017 Dec;36:14-19. doi: 10.1016/j.breast.2017.08.006. Epub 2017 Aug 29. Review.
Esposito E, Di Micco R, Gentilini OD.
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ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3).
Breast. 2017 Oct;35:203-217. doi: 10.1016/j.breast.2017.07.017. Epub 2017 Aug 17.
Paluch-Shimon S, Pagani O, Partridge AH, Abulkhair O, Cardoso MJ, Dent RA, Gelmon K, Gentilini O, Harbeck N, Margulies A, Meirow D, Pruneri G, Senkus E, Spanic T, Sutliff M, Travado L, Peccatori F, Cardoso F.
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Less is more. Breast conservation might be even better than mastectomy in early breast cancer patients.
Breast. 2017 Oct;35:32-33. doi: 10.1016/j.breast.2017.06.004. Epub 2017 Jun 20. Review.
Gentilini OD, Cardoso MJ, Poortmans P.
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Ipsilateral axillary recurrence after breast conservative surgery: The protective effect of whole breast radiotherapy.
Radiother Oncol. 2017 Jan;122(1):37-44. doi: 10.1016/j.radonc.2016.12.021. Epub 2017 Jan 4.
Gentilini O, Botteri E, Leonardi MC, Rotmensz N, Vila J, Peradze N, Thomazini MV, Jereczek BA, Galimberti V, Luini A, Veronesi P, Orecchia R.
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Contralateral risk reducing mastectomy in patients with sporadic breast cancer. Benefits and hazards.
Eur J Surg Oncol. 2016 Jul;42(7):913-8. doi: 10.1016/j.ejso.2016.04.054. Epub 2016 May 3. Review. PMID: 27189832
Boccardo C, Gentilini O.
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Staging the Axilla in Early Breast Cancer: Will Imaging Replace Surgery?
JAMA Oncol. 2015 Aug 20. doi: 10.1001/jamaoncol.2015.2337. [Epub ahead of print]. PMID: 26291922
Gentilini O, Veronesi U.
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Overall survival according to type of surgery in young (≤40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy.
Breast. 2015 Feb 23 [Epub ahead of print].
Vila J, Gandini S, Gentilini O.
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Intraoperative radiotherapy versus external radiotherapy for early breast cancer (ELIOT): a randomised controlled equivalence trial.
Lancet Oncol. 2013 Dec;14(13):1269-77. doi: 10.1016/S1470-2045(13)70497-2. Epub 2013 Nov 11.
Veronesi U, Orecchia R, Maisonneuve P, Viale G, Rotmensz N, Sangalli C, Luini A, Veronesi P, Galimberti V, Zurrida S, Leonardi MC, Lazzari R, Cattani F, Gentilini O, Intra M, Caldarella P, Ballardini B.
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Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial.
Lancet Oncol. 2013 Apr;14(4):297-305. doi: 10.1016/S1470-2045(13)70035-4. Epub 2013 Mar 11. Erratum in: Lancet Oncol. 2013 Jun;14(7):e254.
Galimberti V, Cole BF, Zurrida S, Viale G, Luini A, Veronesi P, Baratella P, Chifu C, Sargenti M, Intra M, Gentilini O, Mastropasqua MG, Mazzarol G, Massarut S, Garbay JR, Zgajnar J, Galatius H, Recalcati A, Littlejohn D, Bamert M, Colleoni M, Price KN, Regan MM, Goldhirsch A, Coates AS, Gelber RD, Veronesi U; International Breast Cancer Study Group Trial 23-01 investigators.
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Abandoning sentinel lymph node biopsy in early breast cancer? A new trial in progress at the European Institute of Oncology of Milan (SOUND: Sentinel node vs Observation after axillary UltraSouND).
Breast. 2012 Oct;21(5):678-81. doi: 10.1016/j.breast.2012.06.013. Epub 2012 Jul 25.
Gentilini O, Veronesi U.
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