Fabio Ciceri

Biography

Professor Fabio Ciceri is the Head of the Department of Hematology and Bone Marrow Transplantation and the Department of Hematological Oncology of the San Raffaele Research Hospital in Milan. Since 2018, he has been Full Professor of Hematology at the Vita-Salute San Raffaele University, where he also runs the School of Specialization in Hematology.

He graduated from the Faculty of Medicine and Surgery from the University of Pavia, followed by a specialization in rheumatology at the University of Ferrara and a specialization in hematology at the University of Milan.

Professor Fabio Ciceri is active in the field of hematology, treating acute leukemia, aggressive lymphomas, myeloproliferative neoplasms and anemia, participating in the development of clinical trials, both observational and prospective and interventional. Over the years of his career, he has acquired broad skills in the field of autologous and allogeneic bone marrow transplantation using any source tissue and from all available donors (compatible relative, non-blood, haploidentical relative) for the treatment of blood cancers, solid tumors and non-neoplastic diseases such as autoimmune, neuroinflammatory diseases and hemoglobinopathy.

His research activities in this area have made transplantation from a partially matched haploidentical donor available as a possible treatment for high-risk hematologic cancers. Since 1996, Professor Ciceri has been principal investigator in the clinical development of advanced cell therapy, gene therapy and regenerative medicine programs in both oncological and non-oncological diseases. Thus, he contributed to the development of the first advanced cell therapy for the treatment of blood cancer using the suicidal HSV-TK gene to control donor lymphocytes, as well as to the development of gene therapy for the treatment of primary immunodeficiency, metabolic diseases and beta-thalassemia.

His works have been published in such journals as the Annals of Neurology, Science, Bone Marrow and Transplantation, Blood, Cell Transplantation, New England Journal of Medicine, Hematology Oncology, and Lancet Oncology. He cooperates as a reviewer with journals the Blood, Leukemia, Haematologica, Bone Marrow Transplantation and the European Research Council (ERC).

He is a member of expert groups such as the Italian Society of Hematology (SIE), Italian Group for Bone Marrow Transplantation (GITMO), of which he currently chairs, Lombardy Hematology Network (REL), Italian Group for Hematological Diseases in Adults (GIMEMA), European Blood and Marrow Transplantation Group (EBMTG), European Hematology Association (EHA), International Network of Cancer Trial Research (INCTR), International Cardio Oncology Society (ICOS), and European Technology Platform for Nanomedicine (ETPN).

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Education

University of Pavia

Degree in Medicine and Surgery – 1989

Ferrara University

Specialization in Rheumatology – 1995

University of Milan

Specialization in Hematology – 2001

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Publications

His works have been published in such journals as the Annals of Neurology, Science, Bone Marrow and Transplantation, Blood, Cell Transplantation, New England Journal of Medicine, Hematology Oncology, and Lancet Oncology. He cooperates as a reviewer with journals the Blood, Leukemia, Haematologica, Bone Marrow Transplantation and the European Research Council (ERC).

Latest publications

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.
Nat Med. 2019 Mar 25. doi: 10.1038/s41591-019-0400-z. [Epub ahead of print]. PMID: 30911134
Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini MM, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen DW, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes CJM, Griffioen M, Carrabba MG, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic
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Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT.
2019 Mar 25;10(1):1065. doi: 10.1038/s41467-019-08871-1. PMID: 30911002.
Noviello M, Manfredi F, Ruggiero E, Perini T, Oliveira G, Cortesi F, De Simone P, Toffalori C, Gambacorta V, Greco R, Peccatori J, Casucci M, Casorati G, Dellabona P, Onozawa M, Teshima T, Griffioen M, Halkes CJM, Falkenburg JHF, Stölzel F, Altmann H, Bornhäuser M, Waterhouse M, Zeiser R, Finke J, Cieri N, Bondanza A, Vago L, Ciceri F, Bonini C. Nat Commun.
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Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.
Nat Med. 2019 Jan 21. doi: 10.1038/s41591-018-0301-6. [Epub ahead of print]. PMID: 30664781
Marktel S, Scaramuzza S, Cicalese MP, Giglio F, Galimberti S, Lidonnici MR, Calbi V, Assanelli A, Bernardo ME, Rossi C, Calabria A, Milani R, Gattillo S, Benedicenti F, Spinozzi G, Aprile A, Bergami A, Casiraghi M, Consiglieri G, Masera N, D'Angelo E, Mirra N, Origa R, Tartaglione I, Perrotta S, Winter R, Coppola M, Viarengo G, Santoleri L, Graziadei G, Gabaldo M, Valsecchi MG, Montini E, Naldini
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Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.
Nat Med. 2018 May 28. doi: 10.1038/s41591-018-0036-4. [Epub ahead of print]. PMID: 29808007
Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.
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Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene.
Front Immunol. 2018 Mar 21;9:507. doi: 10.3389/fimmu.2018.00507. eCollection 2018. PMID: 29619024
Casucci M, Falcone L, Camisa B, Norelli M, Porcellini S, Stornaiuolo A, Ciceri F, Traversari C, Bordignon C, Bonini C, Bondanza A.
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Anthracycline-induced cardiotoxicity: A multicenter randomised trial comparing two strategies for guiding prevention with enalapril: The International CardioOncology Society-one trial.
Eur J Cancer. 2018 May;94:126-137. doi: 10.1016/j.ejca.2018.02.005. Epub 2018 Mar 20. PMID: 29567630
Cardinale D, Ciceri F, Latini R, Franzosi MG, Sandri MT, Civelli M, Cucchi G, Menatti E, Mangiavacchi M, Cavina R, Barbieri E, Gori S, Colombo A, Curigliano G, Salvatici M, Rizzo A, Ghisoni F, Bianchi A, Falci C, Aquilina M, Rocca A, Monopoli A, Milandri C, Rossetti G, Bregni M, Sicuro M, Malossi A, Nassiacos D, Verusio C, Giordano M, Staszewsky L, Barlera S, Nicolis EB, Magnoli M, Masson S, Cipol
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Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients.
Open Forum Infect Dis. 2017 Oct 6;4(4):ofx215. doi: 10.1093/ofid/ofx215. eCollection 2017 Fall. PMID 29226172.
Mancini N, Greco R, Pasciuta R, Barbanti MC, Pini G, Morrow OB, Morelli M, Vago L, Clementi N, Giglio F, Lupo Stanghellini MT, Forcina A, Infurnari L, Marktel S, Assanelli A, Carrabba M, Bernardi M, Corti C, Burioni R, Peccatori J, Sormani MP, Banfi G, Ciceri F, Clementi M.
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NK cell recovery after haploidentical HSCT with post-transplant cyclophosphamide: dynamics and clinical implications.
Blood. 2017 Oct 6. pii: blood-2017-05-780668. doi: 10.1182/blood-2017-05-780668. [Epub ahead of print]. PMID 28986344.
Russo A, Oliveira G, Berglund S, Greco R, Gambacorta V, Cieri N, Toffalori C, Zito L, Lorentino F, Piemontese S, Morelli M, Giglio F, Assanelli A, Lupo Stanghellini MT, Bonini C, Peccatori J, Ciceri F, Luznik L, Vago L.
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Choosing the Alternative.
Biol Blood Marrow Transplant. 2017 Sep 19. pii: S1083-8791(17)30717-6. doi: 10.1016/j.bbmt.2017.09.009. [Epub ahead of print] No abstract available. PMID 28939457.
Vago L, Ciceri F.
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A New Clinicobiological Scoring System for the Prediction of Infection-Related Mortality and Survival after Allogeneic Hematopoietic Stem Cell Transplantation.
Biol Blood Marrow Transplant. 2017 Aug 12. pii: S1083-8791(17)30632-8. doi: 10.1016/j.bbmt.2017.08.010. [Epub ahead of print]. PMID 28807767.
Forcina A, Rancoita PMV, Marcatti M, Greco R, Lupo-Stanghellini MT, Carrabba M, Marasco V, Di Serio C, Bernardi M, Peccatori J, Corti C, Bondanza A, Ciceri F.
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