Fabio Ciceri - 预约 - GSD - 意大利医院集团

个人简介

Fabio Ciceri教授现任米兰圣拉斐尔研究医院血液病和骨髓移植科以及血液肿瘤科主任。他自2018年起任圣拉斐尔生命健康大学血液学正教授，负责管理血液学专业学院。

他毕业于帕维亚大学医学院，后获得费拉拉大学风湿病学专业学位和米兰大学血液学专业学位。

Ciceri教授主攻血液学、急性白血病治疗、侵袭性淋巴瘤、骨髓增殖性肿瘤和贫血相关领域，参与开发观察性、前瞻性和干预性临床试验。他熟练掌握多种利用源组织和所有可用供者（相容亲属、非血缘供者、半相合亲属）细胞进行自体和异体骨髓移植以治疗血癌、实体肿瘤和非肿瘤性疾病（如自身免疫性疾病、神经炎症性疾病和血红蛋白病）的治疗手段。

他在这一领域开展的研究工作使得部分匹配的半相合供者的移植成为了一种可能的高危血液系统癌症治疗方式。自1996年以来，Ciceri教授一直在肿瘤学和非肿瘤学疾病的先进细胞疗法、基因疗法和再生医学项目的临床开发中担任主要研究者。他促成了首个利用HSV-TK自杀基因控制供者淋巴细胞治疗血癌的先进细胞疗法，以及用于治疗原发性免疫缺陷、代谢性疾病和β-珠蛋白生成障碍性贫血的基因疗法。

Ciceri教授的著作已在the Annals of Neurology、Science、Bone Marrow and Transplantation、Blood、Cell Transplantation、New England Journal of Medicine、Hematology Oncology和Lancet Oncology等期刊上发表。此外，他还担任诸多期刊（the Blood、Leukemia、Haematologica、Bone Marrow Transplantation）及欧洲研究委员会（ERC）审稿人。

他是意大利血液学会（SIE）、意大利骨髓移植工作组（简称GITMO，目前担任主席职务）、伦巴第血液学网络（REL）、意大利成人血液病小组（GIMEMA）、欧洲血液和骨髓移植组（EBMTG）、欧洲血液学协会（EHA）、国际癌症治疗和研究网络（INCTR）、国际心脏肿瘤学会（ICOS）和欧洲纳米医学技术平台（ETPN）等专家组成员。

教育背景

帕维亚大学

1989年，医学学位

费拉拉大学

1995年，风湿病学专业学位

米兰大学

2001年，血液学专业学位

多媒体中心

白血病：类型、症状和创新治疗

出版物

他的著作已在theAnnals of Neurology、Science、Bone Marrow and Transplantation、Blood、Cell Transplantation、New England journal of Medicine、Hematology Oncology 和Lancet Oncology等期刊上发表。此外，他还担任诸多期刊（theBlood、Leukemia、Haematologica、Bone Marrow Transplantation）及欧洲研究委员会（ERC）审稿人。

最新出版物

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.

Nat Med. 2019 Mar 25. doi: 10.1038/s41591-019-0400-z. [Epub ahead of print]. PMID: 30911134

Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini MM, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen DW, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes CJM, Griffioen M, Carrabba MG, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic

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Bone marrow central memory and memory stem T-cell exhaustion in AML patients relapsing after HSCT.

2019 Mar 25;10(1):1065. doi: 10.1038/s41467-019-08871-1. PMID: 30911002.

Noviello M, Manfredi F, Ruggiero E, Perini T, Oliveira G, Cortesi F, De Simone P, Toffalori C, Gambacorta V, Greco R, Peccatori J, Casucci M, Casorati G, Dellabona P, Onozawa M, Teshima T, Griffioen M, Halkes CJM, Falkenburg JHF, Stölzel F, Altmann H, Bornhäuser M, Waterhouse M, Zeiser R, Finke J, Cieri N, Bondanza A, Vago L, Ciceri F, Bonini C. Nat Commun.

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Intrabone hematopoietic stem cell gene therapy for adult and pediatric patients affected by transfusion-dependent ß-thalassemia.

Nat Med. 2019 Jan 21. doi: 10.1038/s41591-018-0301-6. [Epub ahead of print]. PMID: 30664781

Marktel S, Scaramuzza S, Cicalese MP, Giglio F, Galimberti S, Lidonnici MR, Calbi V, Assanelli A, Bernardo ME, Rossi C, Calabria A, Milani R, Gattillo S, Benedicenti F, Spinozzi G, Aprile A, Bergami A, Casiraghi M, Consiglieri G, Masera N, D'Angelo E, Mirra N, Origa R, Tartaglione I, Perrotta S, Winter R, Coppola M, Viarengo G, Santoleri L, Graziadei G, Gabaldo M, Valsecchi MG, Montini E, Naldini

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Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.

Nat Med. 2018 May 28. doi: 10.1038/s41591-018-0036-4. [Epub ahead of print]. PMID: 29808007

Norelli M, Camisa B, Barbiera G, Falcone L, Purevdorj A, Genua M, Sanvito F, Ponzoni M, Doglioni C, Cristofori P, Traversari C, Bordignon C, Ciceri F, Ostuni R, Bonini C, Casucci M, Bondanza A.

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Extracellular NGFR Spacers Allow Efficient Tracking and Enrichment of Fully Functional CAR-T Cells Co-Expressing a Suicide Gene.

Front Immunol. 2018 Mar 21;9:507. doi: 10.3389/fimmu.2018.00507. eCollection 2018. PMID: 29619024

Casucci M, Falcone L, Camisa B, Norelli M, Porcellini S, Stornaiuolo A, Ciceri F, Traversari C, Bordignon C, Bonini C, Bondanza A.

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Anthracycline-induced cardiotoxicity: A multicenter randomised trial comparing two strategies for guiding prevention with enalapril: The International CardioOncology Society-one trial.

Eur J Cancer. 2018 May;94:126-137. doi: 10.1016/j.ejca.2018.02.005. Epub 2018 Mar 20. PMID: 29567630

Cardinale D, Ciceri F, Latini R, Franzosi MG, Sandri MT, Civelli M, Cucchi G, Menatti E, Mangiavacchi M, Cavina R, Barbieri E, Gori S, Colombo A, Curigliano G, Salvatici M, Rizzo A, Ghisoni F, Bianchi A, Falci C, Aquilina M, Rocca A, Monopoli A, Milandri C, Rossetti G, Bregni M, Sicuro M, Malossi A, Nassiacos D, Verusio C, Giordano M, Staszewsky L, Barlera S, Nicolis EB, Magnoli M, Masson S, Cipol

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Enteric Microbiome Markers as Early Predictors of Clinical Outcome in Allogeneic Hematopoietic Stem Cell Transplant: Results of a Prospective Study in Adult Patients.

Open Forum Infect Dis. 2017 Oct 6;4(4):ofx215. doi: 10.1093/ofid/ofx215. eCollection 2017 Fall. PMID 29226172.

Mancini N, Greco R, Pasciuta R, Barbanti MC, Pini G, Morrow OB, Morelli M, Vago L, Clementi N, Giglio F, Lupo Stanghellini MT, Forcina A, Infurnari L, Marktel S, Assanelli A, Carrabba M, Bernardi M, Corti C, Burioni R, Peccatori J, Sormani MP, Banfi G, Ciceri F, Clementi M.

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NK cell recovery after haploidentical HSCT with post-transplant cyclophosphamide: dynamics and clinical implications.

Blood. 2017 Oct 6. pii: blood-2017-05-780668. doi: 10.1182/blood-2017-05-780668. [Epub ahead of print]. PMID 28986344.

Russo A, Oliveira G, Berglund S, Greco R, Gambacorta V, Cieri N, Toffalori C, Zito L, Lorentino F, Piemontese S, Morelli M, Giglio F, Assanelli A, Lupo Stanghellini MT, Bonini C, Peccatori J, Ciceri F, Luznik L, Vago L.

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Choosing the Alternative.

Biol Blood Marrow Transplant. 2017 Sep 19. pii: S1083-8791(17)30717-6. doi: 10.1016/j.bbmt.2017.09.009. [Epub ahead of print] No abstract available. PMID 28939457.

Vago L, Ciceri F.

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A New Clinicobiological Scoring System for the Prediction of Infection-Related Mortality and Survival after Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant. 2017 Aug 12. pii: S1083-8791(17)30632-8. doi: 10.1016/j.bbmt.2017.08.010. [Epub ahead of print]. PMID 28807767.

Forcina A, Rancoita PMV, Marcatti M, Greco R, Lupo-Stanghellini MT, Carrabba M, Marasco V, Di Serio C, Bernardi M, Peccatori J, Corti C, Bondanza A, Ciceri F.

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