Treatment of acromegaly
When is this procedure indicated?
Medical treatment is indicated in all cases of active acromegaly in which surgical treatment has been found to be non-curative, is contraindicated or is refused by the patient. First-choice treatment involves the prescription of first-generation somatostatin analogs (octreotide LAR and lanreotide AGT). If ineffective, second-level somatostatin analogs (pasireotide) or GH receptor antagonists (pegvisomant) may be prescribed.
How is it performed?
Drugs can be taken by subcutaneous or intramuscular injections. Depending on the prescribed molecule, it can be administered every day of the week or once a month.
The most frequent side effects include skin manifestations at the site of injection (rubor, pain, calor, etc.) and, in the case of somatostatin analogues, gastrointestinal symptoms including diarrhea, nausea, intestinal discomfort are reported with some frequency. These symptoms are in the vast majority of patients, more frequent at the start of therapy (but they resolve themselves after a few administrations), are also of mild entity and resolve within a few days after administration.