PET-CT with 18F-FDG

What is it?

Brain tissue uses glucose for energy purposes and the measurement of brain metabolism is therefore to be considered as an index of neural activity.  For the examination we use the radiopharmaceutical Fluorodeoxyglucose labelledwith Fluor 18 ([18F]FDG) glucose analogue which represents a directly proportional measure of brain glucose metabolism. The analysis of the images includes both a qualitative evaluation of the radiopharmaceutical distribution and a statistical analysis in stereotactic space with SPM (Statistical Parametric Mapping).

When is this exam indicated?

The examination is used to evaluate the signs of a suspected neurodegenerative disease or early dementia, in the differential diagnosis of dementias and their phenotypic variants, in the differential diagnosis of parkinsonism, in the differential diagnosis of primary depression, psychotic disorders and neurodegenerative diseases, in epilepsy, for the localization of the epileptogenic focus in the forms resistant to anti-mycotic therapy in anticipation of possible neurosurgical treatment and finally in encephalitis to support the diagnostic suspicion. A morphological analysis must be carried out along with this procedure.

  • Alzheimer's disease, prodromal and clinical phase
  • Dementia with Lewy bodies (DLB)
  • Fronto-temporal behavioral dementia (bvFTD)
  • Parkinsonism (corticobasal degeneration, progressive supranuclear palsy)
  • Mild Cognitive Impairment
  • Multisystem atrophy (MSA)

How is it performed?

The preparation for the examination requires fasting for at least 6 hours, the suspension of benzodiazepines, barbiturates, neuroleptics that may affect the metabolic activity of the brain and thus affect the result of the examination. A CT or MRI morphological study and the result of neuropsychological tests are required.  The duration of the examination is about 60 minutes; during the first 45 minutes after the intravenous administration of the radiopharmaceutical the patient remains silent, lying down with eyes closed. This is followed by 15 minutes of image acquisition by means of a PET tomograph that provides restraint mechanisms which are not constrictive but make the patient's position comfortable. Immobility of the head is required, therefore collaborative capacity.


  •   Pregnancy
  •   Lactation (suspension of breastfeeding for 24 h)
  •   Inability of the patient to be cooperative during the procedure

Where do we treat it?

At GSD you can find Exams specialists at these departments:

Are you interested in receiving the treatment?

Contact us and we will take care of you.