Samuele Burastero


Dr. Samuele Burastero is an immunologist in the Department of Immunology, Rheumatology, Allergology and Rare Diseases of the IRCCS Ospedale San Raffaele under the supervision of Professor Lorenzo Dagna.

After graduating with honors from the Faculty of Medicine and Surgery of the University of Genoa in 1982, he specialized in respiratory pathophysiology in 1985 and allergology in 1993 at the same university.

Clinically, Dr. Burastero carries out his activities as an allergist specialist in the outpatient clinics of the department.

In terms of research activities, Dr. Burastero is responsible for the Cellular and Molecular Allergology Research Group.

In this regard, the doctor has been studying Th2 inflammation in allergic asthma and the mechanisms of allergen-specific immunotherapy (ASIT) for a long time. Currently, his research activity is focused on the study of biological parameters for monitoring ASIT using a proteomics-based approach; he is also involved in projects aimed at identifying individuals who respond to biological drugs used to treat severe asthma.

Dr. Burastero also started in 2003 a joint project with the chemical industry, active to this day, in the immunotoxicity sector, in which in vitro tests are performed to predict the allergenic potential of chemicals.

He is the author and co-author of more than 100 publications in national and international scientific journals, as well as chapters in books. His Hirsch Index is 35. He constantly participates as a speaker at national and international industry congresses.

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Latest publications

Thermal stability, ligand binding and allergenicity data of Mus m 1.0102 allergen and its cysteine mutants.
Data Brief. 2020 Feb 29;29:105355. doi: 10.1016/j.dib.2020.105355. PMID: 32190721; PMCID: PMC7068051.
Ferrari E, Corsini R, Burastero SE, Tanfani F, Spisni A.
The allergen Mus m 1.0102: Cysteine residues and molecular allergology.
Mol Immunol. 2020 Apr;120:1-12. doi: 10.1016/j.molimm.2020.01.022. Epub 2020 Feb 7. PMID: 32044430.
Ferrari E, Corsini R, Burastero SE, Tanfani F, Spisni A.
T-cell receptor-mediated cross-reactivity to different allergens is driven by recognition of homologous, phylogenetically conserved epitopes
J Allergy Clin Immunol. 2016 Oct;138(4):1237. doi: 10.1016/j.jaci.2016.04.055. Epub 2016 Jul 30. PMID: 27484036.
Burastero SE.
Serum diamine oxidase activity in patients with histamine intolerance.
Int J Immunopathol Pharmacol. 2016 Mar;29(1):105-11. doi: 10.1177/0394632015617170. Epub 2015 Nov 16. PMID: 26574488; PMCID: PMC5806734.
Manzotti G, Breda D, Di Gioacchino M, Burastero SE.
Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, open, parallel-group study.
Ann Allergy Asthma Immunol. 2014 Dec;113(6):671-673.e1. doi: 10.1016/j.anai.2014.09.009. Epub 2014 Oct 7. PMID: 25304342.
Di Rienzo V, Cadario G, Grieco T, Galluccio AG, Caffarelli C, Liotta G, Pecora S, Burastero SE.
Phleum pratense manganese superoxide dismutase identified by proteomic: a new candidate grass allergen.
Ann Allergy Asthma Immunol. 2014 Mar;112(3):261. doi: 10.1016/j.anai.2013.12.015. Epub 2014 Jan 10. PMID: 24428968.
Conti A, Alessio M, Pesca M, Soldarini A, Breda D, Pigatto PD, Burastero SE.
Aminoacyl-tRNA synthetase-interacting multifunctional protein-1 (AIMP1): the member of a molecular hub with unexpected functions, including CD4 T cell homeostasis.
Clin Immunol. 2012 Jun;143(3):207-9. doi: 10.1016/j.clim.2012.03.006. Epub 2012 Apr 6. PMID: 22542741.
Clin Immunol. 2012 Jun;143(3):207-9. doi: 10.1016/j.clim.2012.03.006. Epub 2012 Apr 6. PMID: 22542741.
In search of a vaccine for mouse allergy: significant reduction of Mus m 1 allergenicity by structure-guided single-point mutations.
Int Arch Allergy Immunol. 2012;157(3):226-37. doi: 10.1159/000327551. Epub 2011 Oct 27. PMID: 22041937
Ferrari E, Breda D, Longhi R, Vangelista L, Nakaie CR, Elviri L, Casali E, Pertinhez TA, Spisni A, Burastero SE.
Broad-spectrum inhibition of HIV-1 by a monoclonal antibody directed against a gp120-induced epitope of CD4.
PLoS One. 2011;6(7):e22081. doi: 10.1371/journal.pone.0022081. Epub 2011 Jul 19. PMID: 21818294; PMCID: PMC3139607.
Burastero SE, Frigerio B, Lopalco L, Sironi F, Breda D, Longhi R, Scarlatti G, Canevari S, Figini M, Lusso P
Human monocytoid THP-1 cell line versus monocyte-derived human immature dendritic cells as in vitro models for predicting the sensitising potential of chemicals.
Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2):259-65. doi: 10.1177/039463200702000206. PMID: 17624238.
Bocchietto E, Paolucci C, Breda D, Sabbioni E, Burastero SE.
Three-year follow-up of clinical and inflammation parameters in children monosensitized to mites undergoing sub-lingual immunotherapy.
Pediatr Allergy Immunol. 2005 Sep;16(6):519-26. doi: 10.1111/j.1399-3038.2005.00301.x. Erratum in: Pediatr Allergy Immunol. 2006 Jun;17(4):318. PMID: 16176400.
Marcucci F, Sensi L, Di Cara G, Salvatori S, Bernini M, Pecora S, Burastero SE.

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