Roberto Furlan



Dr. Roberto Furlan carries out his clinical activities in the Department of Neurology of the IRCCS Ospedale San Raffaele under the supervision of Professor Massimo Filippi.

After graduating from the University of Milan in medicine and surgery in 1991, he received his doctorate from the Biologia Cellulare Open University in London (c/o San Raffaele) in 2002. Finally, in 2007, he specialized in neurology at the Vita Salute San Raffaele in Milan.

Dr. Furlan is the head of the Department of Clinical Neuroimmunology and Deputy Director of the Institute of Experimental Neurology. In addition, the doctor carries out teaching activities as a contract lecturer at the University of Vita-Salute San Raffaele.

From a clinical point of view, the doctor carries out his activities mainly in the general neurology clinic. Both at the clinical and research level, the doctor mainly deals with neuroimmunological (for example, multiple sclerosis) and psychiatric (anxiety and depression) pathologies.

Dr. Furlan is also the President of the Italian Association of Neuroimmunology.

He is the author and co-author of more than 170 publications in national and international scientific journals and book chapters. His Hirsch index is 55. He is a regular speaker at national and international conferences.

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Latest publications

Intravenous and intracerebroventricular injection of adult neurospheres induces clinical recovery in a chronic model of multiple sclerosis
Nature 2003; 422:688- 694
Pluchino S, Quattrini A, Brambilla E, Gritti A, Salani G, Dina G, Galli R, Bergami A, Furlan R, Delcarro U, Amadio S, Comi G, Vescovi Al, Martino G.
Neurosphere-derived multipotent precursors promote long-lasting neuroprotection by an immunomodulatory mechanism
Nature 2005 436:266-271
Pluchino S, Zanotti L, Rossi B, Brambilla E, Ottoboni L, Salani G, Martinello M, Cattalini A, Bergami A, Furlan R, Comi G, Constantin G, Martino G.
Secondary progressive MS: current knowledge and future challenges
Lancet Neurol. 2006 5:343-354
Rovaris M, Confavreux C, Furlan R, Kappos L, Comi G, Filippi M.
IL4 gene delivery to the CNS recruits regulatory T cells and induces clinical recovery in mouse models of multiple sclerosis
Gene Ther. 2008 15: 504-515.
Butti E, Bergami A, Recchia A, Brambilla E, Del Carro U, Amadio S, Cattalini A, Stornaiuolo A, Comi G, Pluchino S, Mavilio F, Martino G, Furlan R.
Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis
J Neurosci. 2009 29:3442-52.
Centonze D, Muzio L, Rossi S, Cavasinni F, De Chiara V, Bergami A, Musella A, D’amelio M, Cavallucci V, Martorana A, Bergamaschi A, Cencioni Mt, Butti E, Comi G, Bernardi G, Cecconi F, Battistini L, Furlan R, Martino G.
IL-17 and IFN- secreting FoxP3+ T cells infiltrate the target tissue in experimental autoimmunity
J Immunol. 2010 185:7467-73
Esposito M, Ruffini F, Bergami A, Garzetti L, Borsellino G, Battistini L, Martino G, Furlan R.
Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
Ann. Neurol. 2012 72:610-62
Verderio C, Muzio L, Turola E, Bergami A, Novellino L, Ruffini F, Riganti L, Corradini I, Francolini M, Garzetti L, Maiorino C, Servida F, Vercelli A, Dalla Libera D, Martinelli V, Comi G, Martino G, Matteoli M, Furlan R.
Allogeneic hematopoietic stem cell transplantation for neuromyelitis optica
Ann. Neurol. 2013 doi: 10.1002/ana.24079.
Greco R, Bondanza A, Vago L, Moiola L, Rossi P, Furlan R, Martino G, Radaelli M, Martinelli V, Carbone MR, Lupo Stanghellini MT, Assanelli A, Bernardi M, Corti C, Peccatori J, Bonini C, Vezzulli P, Falini A, Ciceri F, Comi G.
Increased M1/decreased M2 signature and signs of Th1/Th2 shift in chronic patients with bipolar disorder, but not in those with schizophrenia
Transl Psychiatry. 2014 Jul 1;4:e406. doi: 10.1038/tp.2014.46
Brambilla P, Bellani M, Isola M, Bergami A, Marinelli V, Dusi N, Rambaldelli G, Tansella M, Finardi AM, Martino G, Perlini C, Furlan R.
Myeloid microvesicles in CSF are associated with myelin damage and neuronal loss in mild cognitive impairment and alzheimer disease
Ann. Neurol. 2014 doi: 10.1002/ana.24235.
Agosta F, Dalla Libera D, Gioele Spinelli E, Finardi A, Canu E, Bergami A, Bocchio Chiavetto L, Baronio M, Comi G, Martino G, Matteoli M, Magnani G, Verderio C, Furlan R.
Phagocytes-targeted extracellular vesicles containing IL4 inhibit neuroinflammation in a mouse model of multiple sclerosis
Mol. Ther. 2018 26:2107-2118. doi: 10.1016/j.ymthe.2018.06.024.
Casella G, Colombo F, Finardi A, Ill-Ragaa G, Spinelli A, Podini P, Bastoni M, Descamps H, Muzio L, Furlan R.
Serum neurofilaments increase at PML onset in natalizumab-treated MS patients
Ann Neurol. 2019 85:606-610. doi: 10.1002/ana.25437
Dalla Costa G, Martinelli V, Moiola L, Sangalli F, Colombo B, Finardi A, Cinque P, Kolb EM, Haghikia A, Gold R, Furlan R, Comi G.

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