Paolo Denti

Heart surgeon


Paolo Denti is responsible for the Functional Department of Transcatheter Therapy of Structural Heart Diseases in the Department of Cardiac Surgery at the IRCCS Ospedale San Raffaele in Milan under the supervision of Professor Alessandro Castiglioni.

After graduating in Medicine and Surgery in 2004 with top marks from the University of Vita-Salute San Raffaele, he completed his specialization in cardiac surgery in 2008 at the same university.

He is mainly engaged in the treatment of diseases of the aortic, mitral and tricuspid heart valves (insufficiency and stenosis) and coronary surgery. In addition to the traditional surgical solution, he deals with methods of restoring the mitral valve by mini-thoracotomy by replacing damaged tendons and ligaments (Harpoon, Neochord). In particular, he is engaged in technologies that exclude surgical trauma, suitable for different subgroups of patients, such as percutaneous prosthetics of the aortic valve for aortic stenosis in its various forms (transfemoral and transapical TAVI, valves of the aortic, mitral and tricuspid valves, elimination of paravalvular leak), percutaneous plasty of the mitral and tricuspid valve (for example, Mitraclip, Cardioband, Pascal). Dr. Denti is also an expert in the field of imaging (echocardiography and CT of the heart), which are necessary for the use of new technologies. In recent years, he has devoted himself to the new field of mitral and tricuspid valve replacement by a completely percutaneous route (Tendyne, Tiara, Cardiovalve, and Navigate).

Author and co-author of 100 publications in industry scientific journals and book chapters. His Hirsch Index is 24. Constantly takes part in national and international industry congresses. He conducts educational events (proctorship) around the world to help colleagues correctly use devices for percutaneous treatment of valvulopathies.

He holds several patents for devices for the percutaneous treatment of heart valve diseases. Denti is also a member of the European Cardiothoracic Society (EACTS), the European Society of Cardiology, the Italian Society of Interventional Cardiology (GISE) and the European Society (EACVI).

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Vita Salute San Raffaele University
Degree in Medicine and Surgery - 2004

Vita Salute San Raffaele University
Specialization in Cardiac Surgery - 2009

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Latest publications

1-Year Outcomes After Edge-to- Edge Valve Repair for Symptomatic Tricuspid Regurgitation: Results From the TriValve Registry.
JACC Cardiovasc Interv. 2019 Aug 12;12(15):1451-1461
Mehr M, Taramasso M, Besler C, Ruf T, Connelly KA, Weber M, Yzeiraj E, Schiavi D, Mangieri A, Vaskelyte L, Alessandrini H, Deuschl F, Brugger N, Ahmad H, Biasco L, Orban M, Deseive S, Braun D, Rommel KP, Pozzoli A, Frerker C, Näbauer M, Massberg S, Pedrazzini G, Tang GHL, Windecker S, Schäfer U, Kuck KH, Sievert H, Denti P, Latib A, Schofer J, Nickenig G, Fam N, von Bardeleben S, Lurz P,Maisano F,
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Anatomic Relationship of the Complex Tricuspid Valve, Right Ventricle, and Pulmonary Vasculature: A Review.
JAMA Cardiol. 2019 Apr 17.
Hahn RT, Waxman AB, Denti P, Delhaas T.
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The Tricuspid Valve Relationship With the Right Ventricle and Pulmonary Vasculature.
JACC Cardiovasc Imaging. 2019 Jan 9. pii:S1936-878X(18)31086-6. doi: 10.1016/j.jcmg.2018.11.016
Hahn RT, Delhaas T, Denti P, Waxman AB.
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Outcomes After Current Transcatheter Tricuspid Valve Intervention: Mid-Term Results From the International TriValve Registry.
JACC Cardiovasc Interv. 2019 Jan 28;12(2):155-165. doi: 10.1016/j.jcin.2018.10.022. Epub 2018 Dec 26.
Taramasso M, Alessandrini H, Latib A, Asami M, Attinger-Toller A, Biasco L, Braun D, Brochet E, Connelly KA, Denti P, Deuschl F, Englmeier A, Fam N, Frerker C, Hausleiter J, Himbert D, Ho E, Juliard JM, Kaple R, Kreidel F, Kuck KH, Ancona M, Lauten A, Lurz P, Mehr M, Nazif T, Nickening G, Pedrazzini G, Pozzoli A, Praz F, Puri R, Rodés-Cabau J, Schäfer U, Schofer J, Sievert H, Sievert K, Tang GHL,
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Mid-term outcomes (up to 5 years) of percutaneous edge-toedge mitral repair in the real-world according to regurgitation mechanism: A single-center experience.
Catheter Cardiovasc Interv. 2018 Dec 27. doi:10.1002/ccd.28029
Buzzatti N, Denti P, Scarfò IS, Giambuzzi I, Schiavi D, Ruggeri S, Castiglioni A, De Bonis M, La Canna G, Alfieri O.
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Optimizing mitral repair in functional regurgitation: transcatheter annuloplasty can counteract left ventricle-mitral ring mismatch.
EuroIntervention. 2018 Jan 23. pii: EIJ-D-17-01022. doi: 10.4244/EIJ-D-17-01022
Buzzatti N, Denti P, Alfieri O, La Canna G.
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Systolic anterior motion after mitral valve repair: a predictive computational model.
Interact Cardiovasc Thorac Surg. 2017 Oct 1;25(4):513-519. doi:10.1093/icvts/ivx186.
Denti P, Pozzoli A, Geretto A, Vicentini L, Di Sanzo S, Monaco F, Crivellari M, Buzzatti N, De Bonis M, La Canna G, Redaelli A, Alfieri O.
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Beating- Heart Mitral Valve Repair Using a Novel ePTFE Cordal Implantation Device: Prospective Trial.
J Am Coll Cardiol.2017 Oct 26. pii: S0735-1097(17)41363-5. doi: 10.1016/j.jacc.2017.10.062.
Gammie JS, Bartus K, Gackowski A, D'Ambra MN, Szymanski P, Bilewska A, Kusmierczyk M, Kapelak B, Rzucidlo-Resil J, Moat N, Duncan A, Yadev R, Livesey S, Diprose P, Gerosa G, D'Onofrio A, Pitterello D, Denti P, La Canna G, De Bonis M, Alfieri O, Hung J, Kolsut P.
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The big parade: emerging percutaneous mitral and tricuspid valve devices.
EuroIntervention. 2017 Sep 24;13(AA):AA51-AA59. doi: 10.4244/EIJ-D-17-00571
Natarajan D, Joseph J, Denti P, Redwood S, Prendergast B.
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Transcatheter Treatment of Severe Tricuspid Regurgitation with the Edgeto- Edge: MitraClip Technique.
Circulation. 2017 Mar 23. pii: CIRCULATIONAHA.116.024848.
Nickenig G, Kowalski M, Hausleiter J, Braun D, Schofer J, Yzeiraj E, Rudolph V, Friedrichs K, Maisano F, Taramasso M, Fam NP, Bianchi G, Bedogni F, Denti P, Alfieri O, Latib A, Colombo A, Hammerstingl C, Schueler R
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Clinical and anatomical predictors of MitraClip therapy failure for functional mitral regurgitation: single central clip strategy in asymmetric tethering.
Int J Cardiol. 2015 Mar 18;186:286-288
Taramasso M, Denti P, Latib A, Guidotti A, Buzzatti N, Pozzoli A, Di Giannuario G, La Canna G, Colombo A, Alfieri O, Maisano F.
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Transcatheter treatment of chronic mitral regurgitation with the MitraClip System: an Italian consensus statement.
J. Cardiovasc Med (Hagerstown). 2014 Mar;15(3):173-88. doi: 10.2459/JCM.
Maisano F., Francesco Alamanni F., Alfieri O, Bartorelli A, Bedogni F, Bovenzi FM, Bruschi G, Colombo A, Cremonesi A, Denti P, Ettori F, Klugmann S, La Canna G, Martinelli L, Menicanti L, Metra M, Oliva F, Padeletti L, Parolari A, Santini F, Senni M, Tamburino C, Ussia GP, Romeo F on behalf of the Italian Federation of Cardiology (FIC), Italian Society of Cardiology, (SIC), Italian Association of
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Devices for percutaneous mitral valve repair.
Cardiovasc Transl Res. 2014 Jan 23. 2014 Apr;7(3):266-81.
Denti P, Maisano F., Alfieri O.
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Direct access transcatheter mitral annuloplasty with a sutureless and adjustable device: preclinical experience.
Eur J Cardiothorac Surg. 2012 Sep;42(3):524-9.
Maisano F, Vanermen H, Seeburger J, Mack M, Falk V, Denti P, Taramasso M, Alfieri O.
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Alfieri stitch and its impact on mitral clip.
Eur J Thor card Surg. 2011 Jun;39(6):807-8
Ottavio Alfieri and Paolo Denti.
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