Ottavio Alfieri

Heart surgeon


Professor Ottavio Alfieri currently holds the position of Senior Consultant of the Department of Cardiac Surgery of Ospedale San Raffaele. He is the President of the Alfieri Heart Foundation, established to support research and innovation at the Ospedale San Raffaele. From 1996 to 2017, he was Director of the Department of Cardiac Surgery of the Ospedale San Raffaele in Milan and Professor of Cardiac Surgery at the Vita Salute San Raffaele University.

At the beginning of his career, he devoted himself to the treatment of congenital heart defects, first in Italy, in Bergamo, and then in the United States as a clinical fellow at Clinical Fellow al Children's Hospital in Buffalo, New York, and as a research associate at the University of Alabama at Birmingham. His experience with adult cardiac surgery began in 1980 at the St. Antonius Hospital in Nieuwegein, the Netherlands, where he worked for 6 years in a team of surgeons. From 1982 to 1986 he was a visiting professor at the University of Gdansk (Poland). Returning to Italy in 1986, he became the Head of the Cardiac Surgery Department of the Spedali Civili in Brescia. Ten years later he moved to San Raffaele in Milan. He was an Associate Professor at: University of Brescia, Catholic University of the Sacred Heart in Rome, University of Pisa, and University of Bio-Medico Campus in Rome.

With more than 15,000 major cardiac surgeries, his main interest is the surgery of heart valve diseases, in particular mitral valve plasty. In the early 1990s, he developed the Edge-to-Edge technique (Alfieri mitral repair), an original method of mitral valve plasty, which is the basis of the most widely used percutaneous technology in the world for the correction of mitral insufficiency. The company has numerous patents for devices used to treat heart valve diseases. Over the past 15 years, he has actively promoted an interdisciplinary approach to the treatment of heart disease. In particular, he promoted the introduction of transcatheter technologies into everyday cardiac surgery practice.

He is the author or co-author of more than 600 peer-reviewed publications related to many areas of the cardiac surgery discipline, and the author of several books.

In 2011, he was President of the European Society of Cardio-Thoracic Surgery (EACTS). In 2011, the Municipality of Milan awarded him the Ambrogino d'Oro Award. In 2012, he was Chairman of the task force on European guidelines for the treatment of heart valve diseases and coordinator for the revision in 2017. In 2018, he received a gold medal from the European Society of Cardiology for his scientific contribution in the field of cardiology. He is a member of ESC, EACTS, AATS, and STS.

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University of Parma
Degree of Doctor of Medicine and Surgery — 1971

University of Parma
Specialization in General Surgery — 1976

University of Bari
Specialization in Cardiovascular Surgery — 1979

Royal Dutch Medical Association, Utrecht,
Specialization in Cardiopulmonary Surgery — 1981

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Latest publications

The year in cardiology 2016: valvular heart disease.
Eur Heart J. 2017 Mar 1;38(9):628-633. doi: 10.1093/eurheartj/ehw636. Review. PubMed PMID: 28043978
Alfieri O, Vahanian A
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Expansion of the treatment toolbox for mitral regurgitation
Lancet. 2017 Aug 19;390(10096):722-724. doi: 10.1016/S0140-6736(17)31797-X. PubMed PMID: 28831982
Alfieri O, Buzzatti N.
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Mid-term outcomes of concomitant surgical ablation of atrial fibrillation in patients undergoing cardiac surgery for hypertrophic cardiomyopathy
Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1112-1118. doi: 10.1093/ejcts/ezx017. PubMed PMID: 28329110
Lapenna E, Pozzoli A, De Bonis M, La Canna G, Nisi T, Nascimbene S, Vicentini L, Di Sanzo S, Del Forno B, Schiavi D, Alfieri O
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Can Perceval sutureless valve reduce the rate of patient-prosthesis mismatch?
Eur J Cardiothorac Surg. 2017 Jun 1;51(6):1093-1099. doi: 10.1093/ejcts/ezx009. PubMed PMID: 28329177
Belluschi I, Moriggia S, Giacomini A, Del Forno B, Di Sanzo S, Blasio A, Scafuri A, Alfieri O.
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Does implantation of a single clip provide reliable durability after transcatheter mitral repair?
Eur J Cardiothorac Surg. 2017 Jul 1;52(1):137-142. doi: 10.1093/ejcts/ezx044. PubMed PMID: 28329199
Buzzatti N, Denti P, La Canna G, Schiavi D, Vicentini L, Scarfò IS, Caso I, De Bonis M, Alfieri O
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Long-term results (up to 14 years) of the clover technique for the treatment of complex tricuspid valve regurgitation.
Eur J Cardiothorac Surg. 2017 Jul 1;52(1):125-130. doi: 10.1093/ejcts/ezx027. PubMed PMID: 28329369
De Bonis M, Lapenna E, Di Sanzo S, Del Forno B, Pappalardo F, Castiglioni A, Vicentini L, Pozzoli A, Giambuzzi I, Latib A, Schiavi D, La Canna G, Alfieri O.
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Use of Echocardiography for Guiding Percutaneous Tricuspid Valve Procedures.
JACC Cardiovasc Imaging. 2017 Oct;10(10 Pt A):1194-1198. doi: 10.1016/j.jcmg.2016.10.011. Epub 2017 Mar 15. PubMed PMID: 28330659.
Agricola E, Ancona F, Stella S, Rosa I, Marini C, Spartera M, Denti P, Margonato A, Hahn RT, Alfieri O, Colombo A, Latib A.
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Mitral Valve-in-Ring Implantation With a Dedicated Transcatheter Mitral Valve Replacement System.
JACC Cardiovasc Interv. 2017 Oct 9;10(19):2012-2014. doi: 10.1016/j.jcin.2017.08.019. PubMed PMID: 28982565
Cheung A, Denti P, Kiaii B, Bagur R, Webb J, Latib A, Alfieri O.
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Second cross-clamping after mitral valve repair for degenerative disease in contemporary practice.
Eur J Cardiothorac Surg. 2018 Jul 1;54(1):91-97. doi: 10.1093/ejcts/ezx507. PubMed PMID: 29370363
De Bonis M, Lapenna E, Giambuzzi I, Meneghin R, Affronti G, Pappalardo F, Castiglioni A, Trumello C, Buzzatti N, Giacomini A, Raimondi Lucchetti M, Alfieri. O.
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Treatment of functional mitral regurgitation in chronic heart failure: can we get a 'proof of concept' from the MITRA-FR and COAPT trials?
Eur J Heart Fail. 2019 Jul;21(7):852-861. doi: 10.1002/ejhf.1491. Epub 2019 May 22. Review. PubMed PMID: 31116485
Senni M, Adamo M, Metra M, Alfieri O, Vahanian A.
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Percutaneous treatment of mitral valve regurgitation: Where do we stand?
Int J Cardiol. 2019 Aug 1;288:137-139. doi:10.1016/j.ijcard.2018.10.004. Review. PubMed PMID: 31101228
Sala A, Alfieri O.
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Transcatheter or surgical repair for degenerative mitral regurgitation in elderly patients: A propensity-weighted analysis.
J Thorac Cardiovasc Surg. 2019 Jul;158(1):86-94.e1. doi: 10.1016/j.jtcvs.2019.01.023. Epub 2019 Jan 22. PubMed PMID: 30797588.
Buzzatti N, Van Hemelrijck M, Denti P, Ruggeri S, Schiavi D, Scarfò IS, Reser D, Taramasso M, Weber A, La Canna G, De Bonis M, Maisano F, Alfieri O.
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Mid-term outcomes (up to 5 years) of percutaneous edge-to-edge mitral repair in the real-world according to regurgitation mechanism: A single-center experience.
Catheter Cardiovasc Interv. 2018 Dec 27. doi: 10.1002/ccd.28029. [Epub ahead of print] PubMed PMID: 30592134
Buzzatti N, Denti P, Scarfò IS, Giambuzzi I, Schiavi D, Ruggeri S, Castiglioni A, De Bonis M, La Canna G, Alfieri O
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Informed decision-making in patients with valvular disease.
Nat Rev Cardiol. 2019 Feb;16(2):81-82. doi: 10.1038/s41569-018-0146-1. PubMed PMID:30568276.
Alfieri O.
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How Huge is the Target for Percutaneous Treatment of Tricuspid Regurgitation?
Int J Cardiol. 2017 Aug 1;240:154-156. doi:10.1016/j.ijcard.2017.03.005. Epub 2017 Mar 6. PubMed PMID: 28285795
Sala A, Alfieri O.
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