Nadia Gisella Di Muzio

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Specialty:

Oncology Radiotherapy

Profession:

Radiation oncologist

Location:

Department of Radiotherapy @ Ospedale San Raffaele

Languages:

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Biography

Prof. Nadia Gisella Di Muzio is the Head of the Radiotherapy Unit of IRCCS Ospedale San Raffaele in Milan, and responsible for Prostatic Brachytherapy and Intraoperative Radiotherapy in the same Institute. She is also a tutor for the School of Specialization in Medical Physics at the University of Milan and for the School of Specialization in Radiotherapy at the Faculty of Medicine of the University of Milan-Bicocca and professor at the University Vita-Salute San Raffaele.

She has worked as a doctor at the Radiochemotherapy Service of Ospedale San Raffaele in Milan since 1994, dealing with integrated radiochemotherapy treatment protocols for head and neck neoplasms and phase III chemotherapy treatment protocols for metastatic colorectal and breast tumors. She focuses on prostate cancer. She is President of the Italian Prostatic Brachytherapy Group, and promotes high precision hypofractionated methods for the radical treatment of prostate neoplasms. In addition, she holds specialist courses on the treatment of advanced prostatic pathology. From 2007 to 2008, she was in charge of the Functional Unit of Tomotherapy.

Her training began with a degree in Medicine and Surgery with honors in 1988 at the University of Milan. Then, she obtained specialization in Radiation Oncology with honors in the same university followed by a scholarship on the combined treatment of chemo-radiation of gynecological tumors, and then other scholarships related to cranial irradiation in pediatric patients undergoing bone marrow transplantation for leukemia and breast cancer provided by Ospedale San Raffaele in Milan. She has had some periods of residence abroad (America-University of Wisconsin and NY University New York) to get training in the use of high-tech radiotherapy equipment. Relatively recently, in 2009, she attended the Master program “Managerial Staff Training” for managers of Outpatient Area complex structure at Bocconi University in Milan.

She is a member of important Italian and international scientific societies such as SIURO, ESTRO and AIOM. Since 2013, he has been vice-president of AIRO Lombardia. She is also a member of the Scientific Committee of the Center for Hadrontherapy in Pavia and the Candiolo Cancer Institute.

She is the author of numerous book chapters and more than 200 publications (3500 citations and H-index of 31 - Google Scholar) published in prestigious scientific journals, where she is also a reviewer.

Education

University of Milan

Degree in Medicine and Surgery – 1988

University of Milan

Specialization in radiation therapy for cancer – 1992

Madison University (USA)

Internship in the Department of Radiation Oncology on the use of the tomotherapy system – 2004

University of Milan Bocconi

Management training course for managers of the complex structure “Zone of the hospital” – 2009

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Publications

Latest publications

Moderately Hypofractionated Helical IMRT, FDG-PET/CT-guided, for Progressive Malignant Pleural Mesothelioma in Patients With Intact Lungs.

Clin Lung Cancer. 2019 Jan;20(1):e29-e38. doi: 10.1016/j.cllc.2018.08.019.

Fodor A, Broggi S, Incerti E, Dell'Oca I, Fiorino C, Samanes Gajate AM, Pasetti M, Cattaneo MG, Passoni P, Gianolli L, Calandrino R, Picchio M, Di Muzio N.

A TCP-based early regression index predicts the pathological response in neo-adjuvant radio-chemotherapy of rectal cancer.

Radiother Oncol. 2018 Sep;128(3):564-568. doi: 10.1016/j.radonc.2018.06.019

Fiorino C, Gumina C, Passoni P, Palmisano A, Broggi S, Cattaneo GM, Di Chiara A, Esposito A, Mori M, Raso R, Ronzoni M, Rosati R, Slim N, De Cobelli F, Calandrino R, Di Muzio NG.

Moderate Hypofractionation with Simultaneous Integrated Boost in Prostate Cancer: Long-term Results of a Phase I-II Study.

Clin Oncol (R Coll Radiol). 2016 Mar, 28(8), pp. 490-500. pii: S0936-6555(16)00082-0. doi: 10.1016/j.clon.2016.02.005

Di Muzio NG, Fodor A, Noris Chiorda B, Broggi S, Mangili P, Valdagni R, Dell'Oca I, Pasetti M, Deantoni CL, Chiara A, Berardi G, Briganti A, Calandrino R, Cozzarini C, Fiorino C.

Hematologic Toxicity in Patients Treated With Postprostatectomy Whole-Pelvis Irradiation With Different Intensity Modulated Radiation Therapy Techniques Is Not Negligible and Is Prolonged: Preliminary Results of a Longitudinal, Observational Study.

Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):690-5. doi: 10.1016/j.ijrobp.2016.01.022.

Cozzarini C, Chiorda BN, Sini C, Fiorino C, Briganti A, Montorsi F, Di Muzio N.

Toxicity and efficacy of salvage 11C-Choline PET/CT-guided radiation therapy in patients with prostate cancer lymph nodal recurrence.

BJU Int. 2017 Mar;119(3):406-413. doi: 10.1111/bju.13510.

Fodor A, Berardi G, Fiorino C, Picchio M, Busnardo E, Kirienko M, Incerti E, Dell'Oca I, Cozzarini C, Mangili P, Pasetti M, Calandrino R, Gianolli L, Di Muzio NG.

Radiation Treatment of Lymph Node Recurrence from Prostate Cancer: Is 11C-Choline PET/CT Predictive of Survival Outcomes?

J Nucl Med. 2015 Dec;56(12):1836-42. doi: 10.2967/jnumed.115.163741.

Incerti E, Fodor A, Mapelli P, Fiorino C, Alongi P, Kirienko M, Giovacchini G, Busnardo E, Gianolli L, Di Muzio N, Picchio M.

Higher-than-expected severe (Grade 3-4) late urinary toxicity after postprostatectomy hypofractionated radiotherapy: a single-institution analysis of 1176 patients.

Eur Urol. 2014 Dec;66(6):1024-30. doi: 10.1016/j.eururo.2014.06.012.

Cozzarini C, Fiorino C, Deantoni C, Briganti A, Fodor A, La Macchia M, Noris Chiorda B, Rancoita PM, Suardi N, Zerbetto F, Calandrino R, Montorsi F, Di Muzio N.

Hypofractionated image-guided IMRT in advanced pancreatic cancer with simultaneous integrated boost to infiltrated vessels concomitant with capecitabine: a phase I study.

Int J Radiat Oncol Biol Phys. 2013 Dec 1;87(5):1000-6. doi: 10.1016/j.ijrobp.2013.09.012.

Passoni P, Reni M, Cattaneo GM, Slim N, Cereda S, Balzano G, Castoldi R, Longobardi B, Bettinardi V, Gianolli L, Gusmini S, Staudacher C, Calandrino R, Di Muzio N.

Feasibility of an adaptive strategy in preoperative radiochemotherapy for rectal cancer with image-guided tomotherapy: boosting the dose to the shrinking tumor.

Int J Radiat Oncol Biol Phys. 2013 Sep 1;87(1):67-72. doi: 10.1016/j.ijrobp.2013.05.004.

Passoni P, Fiorino C, Slim N, Ronzoni M, Ricci V, Di Palo S, De Nardi P, Orsenigo E, Tamburini A, De Cobelli F, Losio C, Iacovelli NA, Broggi S, Staudacher C, Calandrino R, Di Muzio N.

Ionizing radiations increase the activity of the cell surface glycohydrolases and the plasma membrane ceramide content.

Glycoconj J. 2012 May 17. doi: 10.1007/s10719-012-9385-2.

Aureli M, Bassi R, Prinetti A, Chiricozzi E, Pappalardi B, Chigorno V, Di Muzio N, Loberto N, Sonnino S.

High-dose adjuvant radiotherapy after radical prostatectomy with or without androgen deprivation therapy.

Int J Radiat Oncol Biol Phys. 2012 Jul 1;83(3):960-5. doi: 10.1016/j.ijrobp.2011.09.007.

Ost P, Cozzarini C, De Meerleer G, Fiorino C, De Potter B, Briganti A, Nagler EV, Montorsi F, Fonteyne V, Di Muzio N.

Lymph nodal metastases: diagnosis and treatment.

J Nucl Med Mol Imaging. 2012 Oct;56(5):421-9

Di Muzio N, Fodor A, Berardi G, Mapelli P, Gianolli L, Messa C, Picchio M.

Gamma knife radiosurgery for treatment of cerebral metastases from non-small-cell lung cancer.

Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e463-8. doi: 10.1016/j.ijrobp.2011.02.051

Motta M, Del Vecchio A, Attuati L, Picozzi P, Perna L, Franzin A, Bolognesi A, Cozzarini C, Calandrino R, Mortini P, di Muzio N.

Predictive factors of [(11)C]choline PET/CT in patients with biochemical failure after radical prostatectomy.

Eur J Nucl Med Mol Imaging. 2010 Feb;37(2):301-9. doi: 10.1007/s00259-009-1253-3.

Giovacchini G, Picchio M, Coradeschi E, Bettinardi V, Gianolli L, Scattoni V, Cozzarini C, Di Muzio N, Rigatti P, Fazio F, Messa C.

IMRT significantly reduces acute toxicity of whole-pelvis irradiation in patients treated with post-operative adjuvant or salvage radiotherapy after radical prostatectomy.

Radiother Oncol. 2009 Nov;93(2):207-12. doi: 10.1016/j.radonc.2009.08.042.

Alongi F, Fiorino C, Cozzarini C, Broggi S, Perna L, Cattaneo GM, Calandrino R, Di Muzio N.

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