Massimo Filippi

Biography

Professor Massimo Filippi was born in Monza on 31/08/1961, graduated in Medicine in 1986, specialized in Neurology in 1990 and in Neurophysiology in 1994.

He is currently Chair of the Neurology and Neurorehabilitation Units, Director of the MS Center, Director of the Neurophysiology Service, and Director of the Neuroimaging Research Unit at IRCCS Scientific Institute San Raffaele and Full Professor of Neurology at Vita-Salute San Raffaele University, Milan, Italy, Director of the Residency School in Neurology, President of the Bacherlor’s Degree in Physiotherapy at the same University.

He is also Visiting Professor at the University of Belgrade (2006) and at Heinrich-Heine University Duesseldorf (2008).

His research activity has always focused on the definition of the mechanisms leading to progressive accumulation of irreversible physical disability and cognitive impairment in various neurological conditions. He is member of various national and international Scientific Societies and Boards and, in some of them, he covered or is covering institutional roles.

Prof. Filippi is author of over 1320 papers published in peer-reviewed journals, he edited several international volumes; he is Editor-in-Chief of the Journal of Neurology, Associate Editor of Human Brain MappingRadiology, and Neurological Sciences, member of the Editorial Boards of many international scientific journals, and reviewer on a regular basis for several others in the neurology and neuroimaging fields, as well as for many Governmental Organizations and private Foundations. He is very often requested as speaker and/or chairman in national and international neurological congresses.

In 2001, Prof. Filippi was awarded the Rita Levi Montalcini Prize for his outstanding contributions to the study of MS, and in 2015 Distinguished Dr Luis Barraquer Ferré Lecture at the LXVII Congress of the Spanish Society of Neurology (SEN).

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Education

University of Milan

Degree in Medicine and Surgery – 1986

University of Milan

Specialization in Neurology – 1990

University of Pavia

Specialization in Neuropathophysiology – 1994

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Publications

He is the member of the Editorial Board of numerous international scientific journals and regularly serves as a reviewer in neurology and neuroimaging, including for government agencies and private foundations. He is also the Editor-in-Chief of the Journal of Neurology and Associate Editor of Radiology and Neurological Sciences. He is the author of over 1000 peer-reviewed scientific publications with a total Hirsch index of 116 (Scopus), as well as 196 book chapters.

Latest publications

Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial.
Lancet 2004; 364: 1489-1496
Filippi M, Rovaris M, Inglese M, Barkhof F, De Stefano N, Smith S, Comi G, and the ETOMS Study Group.
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Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study
Lancet Neurol 2006; 5: 213-220 [Epub ahead of print, 2006 January 20]
Filippi M, Wolinsky JS, Comi G and the CORAL Study Group
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Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
Lancet 2008; 371: 2085-2092
Comi G, Pulizzi A, Rovaris M, Abramsky O, Arbizu T, Boiko A, Gold R, Havrdova E, Komoly S, Selmaj KW, Sharrack B, Filippi M for the LAQ/5062 Study Group
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Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial.
Lancet 2009;374:1503-1511 [Epub ahead of print 7 October 2009; doi: 10.1016/S0140-6736(09)61259-9]
Comi G, Martinelli V, Rodegher M, Moiola L, Bajenaru O, Carra A, Elovaara I, Fazekas F, Hartung HP, Hillert J, King J, Komoly S, Lubetzki C, Montalban X, Myhr KM, Ravnborg M, Rieckmann P, Wynn D, Young C, Filippi M for the PreCISe study group
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Assessment of brain system dysfunction through MRI-based connectomics.
Lancet Neurol 2013; 12: 1189-1199 [Epub ahead of print 11 October 2013; doi: 10.1016/S1474-4422(13)70144-3]
Filippi M, van den Heuvel MP, Fornito A, He Y, Hulshoff Pol HE, Agosta F, Comi G, Rocca MA
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Progress towards a neuroimaging biomarker for amyotrophic lateral sclerosis.
Lancet Neurol 2015; 14: 786-788 [doi: 10.1016/S1474-4422(15)00134-9]
Filippi M, Agosta F, Grosskreutz J, Benatar M, Kassubek J, Verstraete E, Turner MR, on behalf of the Neuroimaging Society in ALS (NiSALS)
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MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines.
Lancet Neurol 2016; 15: 292-303 [doi: 10.1016/S1474-4422(15)00393-
Filippi M, Rocca MA, Ciccarelli O, De Stefano N, Evangelou N, Kappos L, Rovira A, Sastre-Garriga J, Tintorè M, Frederiksen JL, Gasperini C, Palace J, Reich DS, Banwell B, Montalban X, Barkhof F, on behalf of the MAGNIMS Study Group.
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Brain network connectivity differs in early-onset neurodegenerative dementia.
Neurology 2017; 89: 1764-1772 [epub ahead of print 27 September 2017; doi: 10.1212/WNL.0000000000004577]
Filippi M, Basaia S, Canu E, Imperiale F, Meani A, Caso F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.
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Long-term disability progression in primary progressive multiple sclerosis: a 15 year study.
Brain 2017; 140: 2814-2819 [epub ahead of print 27 September 2017; doi: 10.1093/brain/awx250]
Rocca MA, Sormani MP, Rovaris M, Caputo D, Ghezzi A, Montanari E, Bertolotto A, Laroni A, Bergamaschi R, Martinelli V, Comi G, Filippi M.
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Brain structural and functional signatures of impulsive-compulsive behaviours in Parkinson's disease.
Mol Psychiatr 2018; 23: 459-466 [Epub ahead of print 7 March 2017; doi: 10.1038/mp.2017.18]
Imperiale F, Agosta F, Canu E, Markovic V, Inuggi A, Jecmenica-Lukic M, Tomic A, Copetti M, Basaia S, Kostic VS, Filippi M.
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Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study
Lancet Neurol 2018; 17: 133-142 [epub ahead of print 21 December 2017; doi: 10.1016/S1474-4422(17)30469-6]
Filippi M, Preziosa P, Meani A, Ciccarelli O, Mesaros S, Rovira A, Frederiksen J, Enzinger C, Barkhof F, Gasperini C, Brownlee W, Drulovic J, Montalban X, Cramer SP, Pichler A, Hagens M, Ruggieri S, Martinelli V, Miszkiel K, Tintorè M, Comi G, Dekker I, Uitdehaag B, Dujmovic-Basuroski I, Rocca MA
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Unraveling ALS due to SOD1 mutation through the combination of brain and cervical cord MRI.
Neurology 2018; 90: e707-e716 [epub ahead of print 24 January 2018; doi: 10.1212/WNL.0000000000005002]
Agosta F, Spinelli EG, Marjanovic IV, Stevic Z, Pagani E, Valsasina P, Salak-Djokic B, Jankovic M, Lavrnic D, Kostic VS, Filippi M.
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Association between pathological and MRI findings in multiple sclerosis: an update.
Lancet Neurol 2019; 18: 198-210 [doi: 10.1016/S1474-4422(18)30451-4]
Filippi M, Brück W, Chard D, Fazekas F, Geurts JJG, Enzinger C, Hametner S, Kuhlmann T, Preziosa P, Rovira A, Schmierer K, Stadelmann C, Rocca MA, for the Attendees of the Correlation between Pathological and MRI findings in MS workshop.
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Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.
Brain 2019; 142: 1858-1975 [epub ahead of print 17 June 2019; doi: 10.1093/brain/awz144]
Filippi M, Preziosa P, Banwell BL, Barkhof F, Ciccarelli O, De Stefano N, Geurts JJG, Paul F, Reich DS, Toosy AT, Traboulsee A, Wattjes MP, Yousry TA, Gass A, Lubetzki C, Weinshenker BG, Rocca MA.
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Changes in functional and structural brain connectome along the Alzheimer’s disease continuum.
Mol Psychiatr 2019 (in press) [epub ahead of print 9 May 2018; doi: 10.1038/s41380-018-0067-8]
Filippi M, Basaia S, Canu E, Imperiale F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.
Read more
Assessment of brain system dysfunction through MRI-based connectomics.
Lancet Neurol 2013; 12: 1189-1199 [Epub ahead of print 11 October 2013; doi: 10.1016/S1474-4422(13)70144-3]
Filippi M, van den Heuvel MP, Fornito A, He Y, Hulshoff Pol HE, Agosta F, Comi G, Rocca MA
Progress towards a neuroimaging biomarker for amyotrophic lateral sclerosis.
Lancet Neurol 2015; 14: 786-788 [doi: 10.1016/S1474-4422(15)00134-9]
Filippi M, Agosta F, Grosskreutz J, Benatar M, Kassubek J, Verstraete E, Turner MR, on behalf of the Neuroimaging Society in ALS (NiSALS)
MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines.
Lancet Neurol 2016; 15: 292-303 [doi: 10.1016/S1474-4422(15)00393-
Filippi M, Rocca MA, Ciccarelli O, De Stefano N, Evangelou N, Kappos L, Rovira A, Sastre-Garriga J, Tintorè M, Frederiksen JL, Gasperini C, Palace J, Reich DS, Banwell B, Montalban X, Barkhof F, on behalf of the MAGNIMS Study Group.
Brain network connectivity differs in early-onset neurodegenerative dementia.
Neurology 2017; 89: 1764-1772 [epub ahead of print 27 September 2017; doi: 10.1212/WNL.0000000000004577]
Filippi M, Basaia S, Canu E, Imperiale F, Meani A, Caso F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.
Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study
Lancet Neurol 2018; 17: 133-142 [epub ahead of print 21 December 2017; doi: 10.1016/S1474-4422(17)30469-6]
Filippi M, Preziosa P, Meani A, Ciccarelli O, Mesaros S, Rovira A, Frederiksen J, Enzinger C, Barkhof F, Gasperini C, Brownlee W, Drulovic J, Montalban X, Cramer SP, Pichler A, Hagens M, Ruggieri S, Martinelli V, Miszkiel K, Tintorè M, Comi G, Dekker I, Uitdehaag B, Dujmovic-Basuroski I, Rocca MA
Unraveling ALS due to SOD1 mutation through the combination of brain and cervical cord MRI.
Neurology 2018; 90: e707-e716 [epub ahead of print 24 January 2018; doi: 10.1212/WNL.0000000000005002]
Agosta F, Spinelli EG, Marjanovic IV, Stevic Z, Pagani E, Valsasina P, Salak-Djokic B, Jankovic M, Lavrnic D, Kostic VS, Filippi M.
Association between pathological and MRI findings in multiple sclerosis: an update.
Lancet Neurol 2019; 18: 198-210 [doi: 10.1016/S1474-4422(18)30451-4]
Filippi M, Brück W, Chard D, Fazekas F, Geurts JJG, Enzinger C, Hametner S, Kuhlmann T, Preziosa P, Rovira A, Schmierer K, Stadelmann C, Rocca MA, for the Attendees of the Correlation between Pathological and MRI findings in MS workshop.
Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.
Brain 2019; 142: 1858-1975 [epub ahead of print 17 June 2019; doi: 10.1093/brain/awz144]
Filippi M, Preziosa P, Banwell BL, Barkhof F, Ciccarelli O, De Stefano N, Geurts JJG, Paul F, Reich DS, Toosy AT, Traboulsee A, Wattjes MP, Yousry TA, Gass A, Lubetzki C, Weinshenker BG, Rocca MA.
Changes in functional and structural brain connectome along the Alzheimer’s disease continuum.
Mol Psychiatr 2020; 25: 230-239 [epub ahead of print 9 May 2018; doi: 10.1038/s41380-018-0067-8]
Filippi M, Basaia S, Canu E, Imperiale F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.
Longitudinal brain connectivity changes and clinical evolution in Parkinson’s disease.
Mol Psychiatr 2021;26: 5429-5440 [epub ahead of print 14 May 2020; doi: 10.1038/s41380-020-0770-0]
Filippi M, Basaia S, Sarasso E, Stojkovic T, Stankovic I, Fontana A, Tomic A, Piramide N, Stefanova E, Markovic V, Kostic VS, Agosta F.
Neural correlates of visuospatial processing in migraine: does the pain network help?
Mol Psychiatr 2021; 26: 6599–6608 [Epub ahead of print 9 Apr 2021; doi: 10.1038/s41380-021-01085-2]
Messina R, Meani A, Riccitelli GC, Colombo B, Filippi M, Rocca MA.
Early predictors of 9-year disability in pediatric multiple sclerosis.
Ann Neurol 2021; 89: 1011-1022 [Epub ahead of print 17 Feb 2021; doi: 10.1002/ana.26052]
De Meo E, Bonacchi R, Moiola L, Colombo B, Sangalli F, Zanetta C, Amato MP, Martinelli V, Rocca MA, Filippi M.
Performance of the 2017 and 2010 revised McDonald criteria in predicting MS diagnosis after a clinically isolated syndrome. A MAGNIMS Study.
Neurology 2022; 98: e1-e14 [Epub ahead of print 29 October 2021; doi: 10.1212/WNL.0000000000013016]
Filippi M, Preziosa P, Meani A, Dalla Costa G, Mesaros S, Drulovic J, Ivanovic J, Rovira A, Tintorè M, Montalban X, Ciccarelli O, Brownlee W, Miszkiel K, Enzinger C, Khalil M, Barkhof F, Strijbis EMM, Frederiksen JL, Cramer S, Fainardi E, Amato MP, Gasperini C, Ruggieri S, Martinelli V, Comi G, Rocca MA, for the MAGNIMS Study Group.

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Contact us and we will take care of you.