Massimo Filippi

Request an appointment

Specialty:

Neurology Neurological and Functional Rehabilitation Rehabilitation

Profession:

Neurologist

Location:

Department of Neurology and Neurorehabilitation @ Ospedale San Raffaele

Languages:

Request an appointment

Biography

Professor Massimo Filippi was born in Monza on 31/08/1961, graduated in Medicine in 1986, specialized in Neurology in 1990 and in Neurophysiology in 1994.

He is currently Chair of the Neurology and Neurorehabilitation Units, Director of the MS Center, Director of the Neurophysiology Service, and Director of the Neuroimaging Research Unit at IRCCS Scientific Institute San Raffaele and Full Professor of Neurology at Vita-Salute San Raffaele University, Milan, Italy, Director of the Residency School in Neurology, President of the Bacherlor’s Degree in Physiotherapy at the same University.

He is also Visiting Professor at the University of Belgrade (2006) and at Heinrich-Heine University Duesseldorf (2008).

His research activity has always focused on the definition of the mechanisms leading to progressive accumulation of irreversible physical disability and cognitive impairment in various neurological conditions. He is member of various national and international Scientific Societies and Boards and, in some of them, he covered or is covering institutional roles.

Prof. Filippi is author of over 1320 papers published in peer-reviewed journals, he edited several international volumes; he is Editor-in-Chief of the Journal of Neurology, Associate Editor of Human Brain Mapping, Radiology, and Neurological Sciences, member of the Editorial Boards of many international scientific journals, and reviewer on a regular basis for several others in the neurology and neuroimaging fields, as well as for many Governmental Organizations and private Foundations. He is very often requested as speaker and/or chairman in national and international neurological congresses.

In 2001, Prof. Filippi was awarded the Rita Levi Montalcini Prize for his outstanding contributions to the study of MS, and in 2015 Distinguished Dr Luis Barraquer Ferré Lecture at the LXVII Congress of the Spanish Society of Neurology (SEN).

Education

University of Milan

Degree in Medicine and Surgery – 1986

University of Milan

Specialization in Neurology – 1990

University of Pavia

Specialization in Neuropathophysiology – 1994

Multimedia gallery

Demyelination disease: what is it?

Multiple sclerosis: what are the symptoms and available treatments?

Do you need an appointment?

Request an appointment

Publications

He is the member of the Editorial Board of numerous international scientific journals and regularly serves as a reviewer in neurology and neuroimaging, including for government agencies and private foundations. He is also the Editor-in-Chief of the Journal of Neurology and Associate Editor of Radiology and Neurological Sciences. He is the author of over 1000 peer-reviewed scientific publications with a total Hirsch index of 116 (Scopus), as well as 196 book chapters.

Latest publications

Interferon beta-1a for brain tissue loss in patients at presentation with syndromes suggestive of multiple sclerosis: a randomised, double-blind, placebo-controlled trial.

Lancet 2004; 364: 1489-1496

Filippi M, Rovaris M, Inglese M, Barkhof F, De Stefano N, Smith S, Comi G, and the ETOMS Study Group.

Effects of oral glatiramer acetate on clinical and MRI-monitored disease activity in patients with relapsing multiple sclerosis: a multicentre, double-blind, randomised, placebo-controlled study

Lancet Neurol 2006; 5: 213-220 [Epub ahead of print, 2006 January 20]

Filippi M, Wolinsky JS, Comi G and the CORAL Study Group

Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

Lancet 2008; 371: 2085-2092

Comi G, Pulizzi A, Rovaris M, Abramsky O, Arbizu T, Boiko A, Gold R, Havrdova E, Komoly S, Selmaj KW, Sharrack B, Filippi M for the LAQ/5062 Study Group

Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial.

Lancet 2009;374:1503-1511 [Epub ahead of print 7 October 2009; doi: 10.1016/S0140-6736(09)61259-9]

Comi G, Martinelli V, Rodegher M, Moiola L, Bajenaru O, Carra A, Elovaara I, Fazekas F, Hartung HP, Hillert J, King J, Komoly S, Lubetzki C, Montalban X, Myhr KM, Ravnborg M, Rieckmann P, Wynn D, Young C, Filippi M for the PreCISe study group

Assessment of brain system dysfunction through MRI-based connectomics.

Lancet Neurol 2013; 12: 1189-1199 [Epub ahead of print 11 October 2013; doi: 10.1016/S1474-4422(13)70144-3]

Filippi M, van den Heuvel MP, Fornito A, He Y, Hulshoff Pol HE, Agosta F, Comi G, Rocca MA

Progress towards a neuroimaging biomarker for amyotrophic lateral sclerosis.

Lancet Neurol 2015; 14: 786-788 [doi: 10.1016/S1474-4422(15)00134-9]

Filippi M, Agosta F, Grosskreutz J, Benatar M, Kassubek J, Verstraete E, Turner MR, on behalf of the Neuroimaging Society in ALS (NiSALS)

MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines.

Lancet Neurol 2016; 15: 292-303 [doi: 10.1016/S1474-4422(15)00393-

Filippi M, Rocca MA, Ciccarelli O, De Stefano N, Evangelou N, Kappos L, Rovira A, Sastre-Garriga J, Tintorè M, Frederiksen JL, Gasperini C, Palace J, Reich DS, Banwell B, Montalban X, Barkhof F, on behalf of the MAGNIMS Study Group.

Brain network connectivity differs in early-onset neurodegenerative dementia.

Neurology 2017; 89: 1764-1772 [epub ahead of print 27 September 2017; doi: 10.1212/WNL.0000000000004577]

Filippi M, Basaia S, Canu E, Imperiale F, Meani A, Caso F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.

Long-term disability progression in primary progressive multiple sclerosis: a 15 year study.

Brain 2017; 140: 2814-2819 [epub ahead of print 27 September 2017; doi: 10.1093/brain/awx250]

Rocca MA, Sormani MP, Rovaris M, Caputo D, Ghezzi A, Montanari E, Bertolotto A, Laroni A, Bergamaschi R, Martinelli V, Comi G, Filippi M.

Brain structural and functional signatures of impulsive-compulsive behaviours in Parkinson's disease.

Mol Psychiatr 2018; 23: 459-466 [Epub ahead of print 7 March 2017; doi: 10.1038/mp.2017.18]

Imperiale F, Agosta F, Canu E, Markovic V, Inuggi A, Jecmenica-Lukic M, Tomic A, Copetti M, Basaia S, Kostic VS, Filippi M.

Prediction of a multiple sclerosis diagnosis in patients with clinically isolated syndrome using the 2016 MAGNIMS and 2010 McDonald criteria: a retrospective study

Lancet Neurol 2018; 17: 133-142 [epub ahead of print 21 December 2017; doi: 10.1016/S1474-4422(17)30469-6]

Filippi M, Preziosa P, Meani A, Ciccarelli O, Mesaros S, Rovira A, Frederiksen J, Enzinger C, Barkhof F, Gasperini C, Brownlee W, Drulovic J, Montalban X, Cramer SP, Pichler A, Hagens M, Ruggieri S, Martinelli V, Miszkiel K, Tintorè M, Comi G, Dekker I, Uitdehaag B, Dujmovic-Basuroski I, Rocca MA

Unraveling ALS due to SOD1 mutation through the combination of brain and cervical cord MRI.

Neurology 2018; 90: e707-e716 [epub ahead of print 24 January 2018; doi: 10.1212/WNL.0000000000005002]

Agosta F, Spinelli EG, Marjanovic IV, Stevic Z, Pagani E, Valsasina P, Salak-Djokic B, Jankovic M, Lavrnic D, Kostic VS, Filippi M.

Association between pathological and MRI findings in multiple sclerosis: an update.

Lancet Neurol 2019; 18: 198-210 [doi: 10.1016/S1474-4422(18)30451-4]

Filippi M, Brück W, Chard D, Fazekas F, Geurts JJG, Enzinger C, Hametner S, Kuhlmann T, Preziosa P, Rovira A, Schmierer K, Stadelmann C, Rocca MA, for the Attendees of the Correlation between Pathological and MRI findings in MS workshop.

Assessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.

Brain 2019; 142: 1858-1975 [epub ahead of print 17 June 2019; doi: 10.1093/brain/awz144]

Filippi M, Preziosa P, Banwell BL, Barkhof F, Ciccarelli O, De Stefano N, Geurts JJG, Paul F, Reich DS, Toosy AT, Traboulsee A, Wattjes MP, Yousry TA, Gass A, Lubetzki C, Weinshenker BG, Rocca MA.

Changes in functional and structural brain connectome along the Alzheimer’s disease continuum.

Mol Psychiatr 2019 (in press) [epub ahead of print 9 May 2018; doi: 10.1038/s41380-018-0067-8]

Filippi M, Basaia S, Canu E, Imperiale F, Magnani G, Falautano M, Comi G, Falini A, Agosta F.