Luca Aldrighetti

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Specialty:

Liver Diseases Gastrointestinal Diseases Gastrointestinal Cancers Oncology

Profession:

Hepatobiliary surgeon

Location:

Department of Hepatobiliary Surgery @ Ospedale San Raffaele

Languages:

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Biography

Luca Aldrighetti is the Head of the Complex Operative Unit of Hepatobiliary Surgery at IRCCS Ospedale San Raffaele and Associate Professor at the University Vita-Salute San Raffaele.

After graduating in Medicine and Surgery with honors from the University of Milan (1989), he specializes in General Surgery and then in Thoracic Surgery with honors at the same university. Since 1989, he works at the Surgical Division of the IRCCS Ospedale San Raffaele, and in 1992 he moves abroad to the Pittsburgh Transplantation Institute - Pittsburgh, PA, USA, where he completes a two-year Surgical Fellowship. In 1994, he returns to the IRCCS Ospedale San Raffaele as the head of the Functional Liver Unit, and then, in 2014, becomes the head of the Complex Operative Unit of Hepatobiliary Surgery.

Prof. Aldrighetti's research and assistance activities are mainly focused on the diagnosis and treatment of hepatobiliary neoplastic diseases, treatment of portal hypertension and liver failure, and monitoring and treatment of the critical surgical patients, with particular attention to surgery of perilous cholangiocarcinomas and primary and metastatic liver neoplasms. As the first operator, he has done over 3000 liver resections (2004-2019). He is one of the world’s leading specialists in minimally invasive liver surgery. In particular, he has initiated and developed the program of laparoscopic liver resections at San Raffaele Clinical Institute, which is the national and international leader in this field, with a series of laparoscopic resections that currently count to more than 1200 cases.

He is President of the Italian Society of Hepatobiliary and Pancreatic Surgery (AICEP). He is Founder, Past President and Scientific-Didactic Responsible of the Italian Group of Minimally Invasive Liver Surgery (I GO MILS), as well as responsible for the realization and coordination of the Italian Registry in which Ospedale San Raffaele is the center with the highest number of inclusions (more than 601 cases since 2015). He is a member of the Council and Chairman of the International Registry Committee 2019-2021 of ILLS (International Laparoscopic Liver Society) and Chairman of the 4th ILLS World Meeting that took place in Rome in May 2023.

He has special skills in surgery of perihilar cholangiocarcinomas; he is the direct developer of preoperative preparation optimization program aimed at reducing risks (complications and mortality) of this type of surgery. His current count is over 250 resections.

The scientific activity of Prof. Aldrighetti is also carried out through multi-institutional international collaborative projects - European and American – related to the outcomes and prognostic factors of hepatobiliary oncological surgery, the impact of ERAS (Enhanced Recovery After Surgery) program in laparoscopic and laparotomic liver resection surgery, the outcomes of laparoscopic liver surgery and ALPPS procedure.

He is an author and co-author of 289 scientific publications in the most prestigious national and international journals, with a large number of citations (8070 – Scopus, 10845 – Google Scholar). His H index is 44 (Scopus) and 51 (Google Scholar). He is a member of 18 national and international scientific societies.

Prof. Aldrighetti holds various specialty courses in liver surgery at both the University Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele.

Education

University of Milan

Degree in Medicine and Surgery – 1989

University of Milan

PhD in Technological Applications and Experimental Methodologies in Surgery – 1995

University of Milan

Specialization in General Surgery – 1997

University Vita-Salute San Raffaele

Specialization in Thoracic Surgery – 2002

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Publications

Latest publications

Case-matched analysis of totally laparoscopic versus open liver resection for HCC. Short and middle term results.

J Surg Oncol 2010; 102: 82-86

Aldrighetti l., Guzzetti E., Pulitanò C., Cipriani F, Catena M., Paganelli M., Ferla G.

What defines “cure” after liver resection for colorectal metastases? Results after 10 years of follow up.

HPB 2010; 12: 244-249

Pulitanò C, Castillo F, Aldrighetti l., Bodingbauer M, Parks RW, Ferla G, Wigmore SJ, Garden OJ.

Hilar cholangiocarcinoma: preoperative liver optimization with multidisciplinary approach. Toward a better outcome.

World J Surg. 2013 Jun;37(6):1388-96.

Ratti F, Cipriani F, Ferla F, Catena M, Paganelli M, Aldrighetti l.

Strategies to increase resectability of patients with Colorectal Liver Metastases: A multi-center case-match analysis of ALPPS versus conventional Two-Stage Hepatectomy.

Ann Surg Oncol. 2015;22(6):1933-42.

Ratti F, Schadde E, Masetti M, Massani M, Zanello M, Serenari M, Cipriani F, Bonariol L, Bassi N, Aldrighetti l, Jovine E.

Recommendations for laparoscopic liver resection: a report from the second international consensus conference held in Morioka.

Ann Surg. 2015 Apr;261(4):619-29.

Wakabayashi G, Cherqui D, Geller DA, Buell JF, Kaneko H, Han HS, Asbun H, OʼRourke N, Tanabe M, Koffron AJ, Tsung A, Soubrane O, Machado MA, Gayet B, Troisi RI, Pessaux P, Van Dam RM, Scatton O, Abu Hilal M, Belli G, Kwon CH, Edwin B, Choi GH, Aldrighetti l, Cai X, Cleary S, Chen KH, Schön MR, Sugioka A, Tang CN, Herman P, Pekolj J, Chen XP, Dagher I, Jarnagin W, Yamamoto M, Strong R, Jagannath P,

Safety and feasibility of laparoscopic liver resection with associated lymphadenectomy for intrahepatic cholangiocarcinoma: a propensity-score based case-matched analysis from a single institution.

Surg Endosc. 2016 May;30(5):1999-2010.

Ratti F, Cipriani F, Ariotti R, Gagliano A, Paganelli M, Catena M, Aldrighetti l.

Impact of totally laparoscopic combined management of colorectal cancer with synchronous hepatic metastases on severity of complications: a propensity-score-based analysis.

Surg Endosc. 2016 Nov;30(11):4934-4945.

Ratti F, Catena M, Di Palo S, Staudacher C, Aldrighetti l.

Impact of ERAS approach and minimally-invasive technique on outcome of patients undergoing liver surgery for hepatocellular carcinoma.

Dig Liver Dis. 2016 Oct;48(10):1243-8.

Ratti F, Cipriani F, Reineke R, Catena M, Comotti L, Beretta L, Aldrighetti l.

Laparoscopic liver resections for hepatocellular carcinoma. Can we extend the surgical indication in cirrhotic patients?

Surg Endosc. 2018 Feb;32(2):617-626.

Cipriani F, Fantini C, Ratti F, Lauro R, Tranchart H, Halls M, Scuderi V, Barkhatov L, Edwin B, Troisi RI, Dagher I, Reggiani P, Belli G, Aldrighetti l, Abu Hilal M.

Diffusion, outcomes and implementation of minimally invasive liver surgery: a snapshot from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry.

Updates Surg. 2017 Sep;69(3):271-283.

Aldrighetti l, Ratti F, Cillo U, Ferrero A, Ettorre GM, Guglielmi A, Giuliante F, Calise F; Italian Group of Minimally Invasive Liver Surgery (I GO MILS).

The Southampton Consensus Guidelines for Laparoscopic Liver Surgery: From Indication to Implementation.

Ann Surg. 2018 Jul;268(1):11-18.

Abu Hilal M, Aldrighetti l, Dagher I, Edwin B, Troisi RI, Alikhanov R, Aroori S, Belli G, Besselink M, Briceno J, Gayet B, D'Hondt M, Lesurtel M, Menon K, Lodge P, Rotellar F, Santoyo J, Scatton O, Soubrane O, Sutcliffe R, Van Dam R, White S, Halls MC, Cipriani F, Van der Poel M, Ciria R, Barkhatov L, Gomez-Luque Y, Ocana-Garcia S, Cook A, Buell J, Clavien PA, Dervenis C, Fusai G, Geller D, Lang H

Laparoscopic vs Open Surgery for Colorectal Liver Metastases.

JAMA Surg. 2018 Nov 1;153(11):1028-1035.

Ratti F, Fiorentini G, Cipriani F, Catena M, Paganelli M, Aldrighetti l.

Multicentre propensity score-matched study of laparoscopic versus open repeat liver resection for colorectal liver metastases.

Br J Surg. 2019 May;106(6):783-789.

Van der Poel MJ, Barkhatov L, Fuks D, Berardi G, Cipriani F, Aljaiuossi A, Lainas P, Dagher I, D'Hondt M, Rotellar F, Besselink MG, aldrighetti l, Troisi RI, Gayet B, Edwin B, Abu Hilal M.

Laparoscopic Versus Open Major Hepatectomy: Analysis of Clinical Outcomes and Cost Effectiveness in a High-Volume Center.

J Gastrointest Surg. 2019 Feb 4. doi: 10.1007/s11605-019-04112-4.

Cipriani F, Ratti F, Cardella A, Catena M, Paganelli M, Aldrighetti l.

A stepwise learning curve to define the standard for technical improvement in laparoscopic liver resections: complexity-based analysis in 1032 procedures.

Updates Surg. 2019 doi: 10.1007/s13304-019-00658-9

Aldrighetti L, Cipriani F, Fiorentini G, Catena M, Paganelli M, Ratti F.

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