Letizia Leocani


Professor Letizia Leocani is a neurologist at the IRCCS Ospedale San Raffaele in Milan and an associate professor of Neurology at the Vita Salute San Raffaele University. She is the head of the Department of Clinical Research of Experimental Neurophysiology and the Center for Magnetic Intracerebral Stimulation - MAGICS of the same institute.

After graduating from the Faculty of Medicine and Surgery of the University of Milan, she received a doctorate in human physiology and a specialization in neurology there. She received clinical and research training at Ospedale San Raffaele (Operating Departments of Neurology and Neurorehabilitation and Clinical Neurophysiology Service, Institute of Experimental Neurology - INSPE) and was a Visiting Research Fellow at the Human Motor Control Section dei National Institutes of Health USA.

Professor Leocani is engaged in neurorehabilitation and innovative technologies aimed at functional recovery, such as non-invasive transcranial magnetic and electrical neuromodulation, as well as clinical and translational neurophysiology, focusing on the identification and quantification of motor, sensory and cognitive dysfunctions through advanced research. Among them are computer optical tomography (OCT), tools for remote digital monitoring of psychophysical functions, electrophysiology, such as electroencephalogram and somatosensory, visual, auditory and motor evoked potentials.

She has been an invited speaker at numerous national and international conferences, author of 18 book chapters and 146 scientific articles in international journals such as Lancet Neurology, Annals of Neurology, Neurology, Brain, Multiple Sclerosis Journal, Journal of Neuroimmunology, Journal of Neurophthalmology, Human Molecular Genetics, International Journal of Molecular Sciences, Plos One, CNS Drugs, Cerebral Cortex, Current Opinion in Neurology, Behavioral Brain Research, Frontiers in Aging Neuroscience, Brain Stimulation.

He is a member of the editorial board of the journals Board di Clinical Neurophysiology Practice, Clinical Neurophysiology, Multiple Sclerosis and Neuroimmunology, Multiple Sclerosis and Demyelinating Disorders and the International Journal of Neurorehabilitation. She is a member of the Scientific Committee of FISM (Italian Multiple Sclerosis Foundation), a member of the European Academy of Neurology (EAN), in which she is co-chair of the Scientific Group on Neurorehabilitation and was co-chair and now a member of the steering Group of the Clinical Research Group on Neurophysiology of the Italian Society of Neurologists, in which she is currently co-coordinator of the research group "Digital Technology, Web and Social Media", was Secretary and Director of the Board of the Italian Society of Psychophysiology (SIPF) and Clinical Neurophysiology (SINC), in the latter also a delegate abroad, and currently coordinator of the Neurostimulation and Diagnostic and Therapeutic Neuromodulation research Group.

In 2018, she joined the association of experts of the International Federation of Clinical Neurophysiology to assess the safety and effectiveness of transcranial magnetic stimulation. In 2020, she was selected by the European Commission to the group of expert evaluators of medical devices for the discipline "neurology".

Read moreRead less


University of Milan
Diploma in Medicine and Surgery - 1992

University of Milan
Doctor of Philosophy in Human Physiology - 1997

University of Milan
Specialization in Neurology-2000

Do you need an appointment?

Contact us and we will take care of you.


Latest publications

Visual Evoked Potentials as a Biomarker in Multiple Sclerosis and Associated Optic Neuritis.
J Neuroophthalmol. 2018;:350-357.
Leocani L., Guerrieri S., Comi G.
Bi-hemispheric repetitive transcranial magnetic stimulation for upper limb motor recovery in chronic stroke: A feasibility study.
Brain Stimul; 11(4):932-934. doi: 10.1016/j.brs.2018.03.013.
Chieffo R, Scopelliti G, Fichera M, Santangelo R, Guerrieri S, Zangen A, Comi G, Leocani L.
Read more
No evidence of disease activity is associated with reduced rate of axonal retinal atrophy in MS.
Neurology 2017, 89, 469-2475.
Pisa M, Guerrieri S, Di Maggio G, Medaglini S, Moiola L, Martinelli V, Comi G, Leocani L.
Read more
Optical Coherence Tomography Reveals Retinal Neuroaxonal Thinning in Frontotemporal Dementia as in Alzheimer's Disease.
J Alzh Dis 2017; 56: 1101-1107.
Ferrari L, Huang SC, Magnani G, Ambrosi A, Comi G, Leocani L.
Read more
Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis.
Lancet Neurol 2017, 16: 797-812.
Petzold Axel, Balcer Laura J, Calabresi Peter A, et al.
Read more
Motor Cortical Plasticity to Training Started in Childhood: The Example of Piano Players.
PLOS One 2016;11.
Chieffo R, Straffi L, Inuggi A, Gonzalez-Rosa JJ, Spagnolo F, Coppi E, Nuara A, Houdayer E, Comi G, Leocani L.
Read more
Noninvasive Neuromodulation in Poststroke Gait Disorders: Rationale, Feasibility, and State of the Art.
Neurorehab Neural Repair 2016;30:71-82.
Chieffo R, Comi G, Leocani L.
Read more
Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study.
Lancet Neurol 2016;15:574-584.
Martinez-Lapiscina EH, Arnow S, Wilson JA, et al.
Read more
Sativex® and clinical-neurophysiological measures of spasticity in progressive multiple sclerosis.
J Neurol. 2015; 262:2520-7.
Leocani L, Nuara A, Houdayer E, Schiavetti I, Del Carro U, Amadio S, Straffi L, Rossi P, Martinelli V, Vila C, Sormani MP, Comi G.
Read more
Age-related changes in motor cortical representation and interhemispheric interactions: a transcranial magnetic stimulation study.
Front Aging Neurosci. 2014 Aug 11;6:209.
Coppi E, Houdayer E, Chieffo R, Spagnolo F, Inuggi A, Straffi L, Comi G, Leocani L.
Read more

Do you need an appointment?

Contact us and we will take care of you.