Cristina Anna Colombo



Professor Cristina Colombo heads the Department of Affective Disorders at the IRCCS Ospedale San Raffaele in Milan, and is also a professor of psychiatry at the Vita Salute San Raffaele University. There she also holds the position of Director of the School of Specialization in Psychiatry and Master of Forensic Psychopathology and Clinical Criminology.

In 1985 she graduated from the Faculty of Medicine and Surgery of the University of Milan, and four years later she specialized in psychiatry. In 1994 she was enrolled in the register of psychotherapists, and in 2001 she received a specialization in clinical criminology. In the period from 2000 to 2003, she develops and coordinates the course of the European Social Fund for the training of researchers and surgeons in biological non-drug interventions in the treatment of depression and the International Workshop on Sleep Deprivation and Chronobiology of Depression.

During her career, she conducted intensive research activities, especially in the field of computer electroencephalography and brain mapping methods, as well as brain imaging methods (CT, MRI, PET). She is also a member of the operating committee of the High-Field Magnetic Resonance Center of Excellence (CERMAC) for the study of the application of functional imaging in psychiatry.

She collaborates with numerous journals as a columnist, is the editor of the section Affective Disorders and the monograph Evidence based assessment of mood disorders for Clinical Neuropsychiatry, Journal of Treatment Evaluation. Since 1998, he has been a member of the scientific committee of the journal Psichiatria e Psicoterapia Analitica. Her articles are published in Genes, Brain and BehaviorPsychopharmacologyJournal of Clinical PsychiatryNeuropsychopharmacologyJournal of Affective DisordersPsychiatry Research.

He is the organizer of international seminars on psychiatry topics, such as new methods of sleep deprivation, chronobiology and depression.

Read moreRead less


University of Milan
Degree of Doctor of Medicine and Surgery - 1985

University of Milan
Specialization in psychiatry - 1989

University of Milan
Specialization in Clinical Criminology - 2001

Multimedia gallery

Do you need an appointment?

Contact us and we will take care of you.


Latest publications

A Homer 1 gene variant influences brain structure and function, lithium effects on white matter, and antidepressant response uin bipolar disorder: a multimodal genetic imaging study
Progress in Neuropsychopharmacology and Biological Psychiatry, 81 (2018) 88-95
Benedetti F., Poletti S., Locatelli C., Mazza E., Lorenzi C., Vitali A., Riberto M., Brioschi S., Vai B., Bollettini I., Melloni E., Aggio V., Falini A., De Bartolomeis A., Colombo C.
Read more
Night sleep influences white matter microstructure in bipolar depression
J affective Disorders 15;218:380-387 (2017)
Benedetti F., Melloni EMT, Dallaspezia S., Bolletini I., Locatelli C, Poletti S., Colombo C.
Effects of CLOCK gene variants and early stress on hopelessness and suicide in bipolar depression
Chronobiology International, Posted online on July 23, 2015
Benedetti F., Riccaboni R., Dallaspezia S., Locatelli C., Smeraldi E., Colombo C.
Read more
White matter microstructure in bipolar disorder is influenced by the serotonin transporter gene polymorphism 5-HTTLPR
(2015) Genes, Brain and Behavior, 14:3, 238-250
Benedetti F., Bollettini I., Poletti S., Locatelli C., Lorenzi C., Pirovano A., Smeraldi E., Colombo C.
Read more
Lithium and GSK-3β promoter gene variants influence cortical gray matter volumes in bipolar disorder
Psychopharmacology DOI 10.1007/s00213-014-3770-4 (2015)
Benedetti F., Poletti S., Radaelli D., Locatelli C., Pirovano A., Lorenzi C., Vai B., Bollettini I., Falini A., Smeraldi E., Colombo C.
Read more
Rapid treatment response of suicidal symptoms to lithium, sleep deprivation, and light therapy (chronotherapeutics) in drug-resistant bipolar depression
J Clin Psychiatry J Clin Psychiatry 2014 75(2): 133-140
Benedetti F., Riccaboni R., Locatelli C., Poletti S., Dallaspezia S., Colombo C. (2014)
Read more
Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder
Neuropsychopharmacology, 38 (2): 313-27
Benedetti F., Bollettini I., Barberi I., Radaelli D., Poletti S., Locatelli C., Pirovano A., Lorenzi C., Colombo C., Smeraldi E.
Read more
Sleep deprivation in mood disorders.
Neuropsychobiology, 64:141-151 (2011)
Benedetti F., Colombo C.
Read more
Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism
J Affect Disord.121(1-2):68-72. Epub 2009 Jun 11.
Benedetti F, Barbini B, Bernasconi A, Fulgosi MC, Dallaspezia S, Gavinelli C, Locatelli C, Lorenzi C, Pirovano A, Radaelli D, Smeraldi E, Colombo C.
Read more
The catechol-O-methyltransferase Val(108/158)Met polymorphism affects antidepressant response to paroxetine in a naturalistic setting
Psychopharmacology, 203(1):155-60. (2009)
Benedetti F., Colombo C., Pirovano A., Marino E., Smeraldi E.
Read more

Do you need an appointment?

Contact us and we will take care of you.