Angelo Manfredi


Professor Angelo Manfredi is Coordinator of Care Area Activities at the Unit of Immunology, Rheumatology, Allergology and Rare Diseases of IRCCS Ospedale San Raffaele directed by Professor Lorenzo Dagna.

Since 2003, he is in charge of the Autoimmunity and Vascular Inflammation Research Unit in the Division of Immunology, Transplantation and Infectious Diseases at the same Institute. Since 2004, he is Associate Professor of Rheumatology at the Faculty of Medicine of the University Vita-Salute San Raffaele in Milan.

After the Degree in Medicine and Surgery at the University of Milan in 1985, he specialized in Allergology and Clinical Immunology at the same university in 1989. From 1987 to 1992, he studied at the University of Minnesota at Saint Paul and, in 1997, at the Marseille Luminy Immunology Center.

His clinical practice focuses on patients with chronic autoimmune-based diseases (systemic autoimmune diseases, connective tissue diseases, systemic vasculitis), with a particular focus on associated rheumatologic damage and management of joint and vascular damage.

His research activity is focused on systemic autoimmune diseases and small and large vessel vasculitis. In recent years, Prof. Manfredi and his collaborators have focused on the mechanisms underlying vascular inflammation, the effects of autoimmunity on tissue repair mechanisms and the identification of biomarkers of prognosis and organ involvement.

He is author and co-author of more than 240 scientific publications in international journals. His papers have received over 15000 citations since 1992, with an H index of 60 as of July 2020 (Top Italian Scientists, He is a corresponding member of the Istituto Lombardo and Accademia di Scienze e Lettere (

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Latest publications

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis.
Sci Transl Med. 2018 Jul 25;10(451). pii: eaao3089. doi: 10.1126/scitranslmed.aao3089.
Maugeri N, Capobianco A, Rovere-Querini P, Ramirez GA, Tombetti E, Valle PD, Monno A, D'Alberti V, Gasparri AM, Franchini S, D'Angelo A, Bianchi ME, Manfredi AA.
Cytotoxic T Cells Is Expanded in Patients with IgG4-Related Disease and Decreases Following Glucocorticoid Treatment.
A CD8α- Subset of CD4+SLAMF7 ArthritisRheumatol. 2018 Jul; 70(7):1133-1143. doi: 10.1002/art.40469.
Della-Torre E, Bozzalla-Cassione E, Sciorati C, Ruggiero E, Lanzillotta M, Bonfiglio S, Mattoo H, Perugino CA, Bozzolo E, Rovati L, Arcidiacono PG, Balzano G, Lazarevic D, Bonini C, Falconi M, Stone JH, Dagna L, Pillai S, Manfredi AA.
Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps.
Pharmacol Res. 2017 123:146-156. pii: S1043-6618(16)30619-3. doi: 10.1016/j.phrs.2016.08.008.
Manfredi AA, Rovere-Querini P, D'Angelo A, Maugeri N.
Chromogranin-A production and fragmentation in patients with Takayasu arteritis. Arthritis Res Ther.
2016 Aug 17;18:187. doi: 10.1186/s13075-016-1082-2
Tombetti E, Colombo B, Di Chio MC, Sartorelli S, Papa M, Salerno A, Bozzolo EP, Tombolini E, Benedetti G, Godi C, Lanzani C, Rovere-Querini P, Del Maschio A, Ambrosi A, De Cobelli F, Sabbadini MG,Baldissera E, Corti A, Manfredi AA
Anti-TNFα agents curb platelet activation in patients with rheumatoid arthritis Ann Rheum Dis.
2016 Aug;75(8):1511-20. doi: 10.1136/annrheumdis-2015-208442.
Manfredi AA, Baldini M, Camera M, Baldissera E, Brambilla M, Peretti G, Maseri A, Rovere-Querini P, Tremoli E, Sabbadini MG, Maugeri N.
Clinical trials in rheumatology. Does one size fit all?
Rheumatology (Oxford). 2016 Jun 15. pii: kew253
Tombetti E, Rovere-Querini P, Manfredi AA.
Parietal and intravascular innate mechanisms of vascular inflammation.
Arthritis Res Ther. 2015 Jan 28;17:16. doi: 10.1186/s13075-015-0528-2.
Ramirez GA, Rovere-Querini P, Sabbadini MG, Manfredi AA
TRPC6 gene variants and neuropsychiatric lupus.
J Neuroimmunol. 2015 Nov 15; 288:21-4. doi: 10.1016/j.jneuroim.2015.08.015.
Rovere-Querini P, Manunta P, Manfredi AA.
Beta-adducin and sodium-calcium exchanger 1 gene variants are associated with systemic lupus erythematosus and lupus nephritis.
Rheumatol Int. 2015 Dec;35(12):1975-83. doi: 10.1007/s00296-015-3298-x
Ramirez GA, Lanzani C, Bozzolo EP, Zagato L, Citterio L, Casamassima N, Canti V, Sabbadini MG, Rovere-Querini P, Manunta P, Manfredi AA
Instructive influences of phagocytic clearance of dying cells on neutrophil extracellular trap generation.
Clin Exp Immunol. 2015 Jan;179(1):24-9. doi:10.1111/cei.12320.
Manfredi, A.A, Covino C, Rovere-Querini, P., Maugeri, N.
Oxidative stress elicits platelet/leukocyte inflammatory interactions via HMGB1: A Candidate for microvessel injury in sytemic sclerosis (2014)
Antioxidants and Redox Signaling, 20 (7), pp. 1060-1074
Maugeri, N., Rovere-Querini, P., Baldini, M., Baldissera, E., Sabbadini, M.G., Bianchi, M.E., Manfredi, A.A.
How macrophages ring the inflammation alarm
Proceedings of the National Academy of Sciences of the United States of America, 111 (8), pp. 2866-2867
Bianchi, M.E., Manfredi, A.A.
Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.
J Thromb Haemost. 2014 Dec;12(12):2074-88.
Maugeri N, Campana L, Gavina M, Covino C, De Metrio M, Panciroli C, Maiuri L, Maseri A, D'Angelo A,Bianchi ME, Rovere-Querini P, Manfredi AA.
Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis.
Arthritis Res Ther. 2014 Nov 14;16(6):479. doi: 10.1186/s13075-014-0479.
Tombetti E, Di Chio MC, Sartorelli S, Papa M, Salerno A, Bottazzi B, Bozzolo EP, Greco M, RovereQuerini P, Baldissera E, Del Maschio A, Mantovani A, De Cobelli F, Sabbadini MG, Manfredi AA.
Procalcitonin in Takayasu arteritis.
J Rheumatol. 2014 Jul;41(7):1564-6. doi:10.3899/jrheum.131340
Tombetti, E., Di Chio, M.C., Sartorelli, S., Segalini, A., Vella, Y., Sabbadini, M.G., Baldissera, E., Manfredi,A.A.

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