Alberto Zangrillo


Professor Alberto Zangrillo is the Head of General and Cardiothoracic Anesthesia and Intensive Care Unit, Head of Clinical Areas of the San Raffaele Hospital in Milan and collaborates with Casa di Cura La Madonnina.

For the Vita-Salute San Raffaele University he holds the roles of Vice Rector for clinical activities and Full Professor of Anesthesiology and Intensive Care.

His training began at the University of Milan, where he graduated in Medicine and Surgery in 1983 and specialized, three years later, in Anesthesia and Intensive Care, and then continued in relevant European centers such as the Queen Charlotte Hospital in London, the Hospital de la Santa Creu i Sant Pau in Barcelona, the Cardio-thoracic Center of Monaco in Monte Carlo, the Hetzer Deutsches Herzzentrum in Berlin and the San Raffaele Hospital.

Professor Alberto Zangrillo is among the top ten world leading physicians in recent years for the number of publications in the field of "anesthesia" and "intensive care" (source: Scopus), the author of more than 800 publications, of which more than 500 in international indexed journals (cited more than 18,000 times, Hindex 64) including randomized studies in The New England Journal of Medicine, JAMA, Circulation and British Medical Journal.

He has won several grants by the Italian Ministry of Health and AIFA (the Italian Medicines Agency), he often participates as Principal Investigator in 48 randomized research protocols, approved by the Ethics Committee of the San Raffaele Hospital. Amongst his many areas of research, his main areas of activity are advanced circulatory support and ventilatory systems (ECMO, VAD, artificial heart), the treatment of acute heart failure, non-invasive ventilation (ICU and inpatient wards), alternative anticoagulant therapies in intensive care, optimizing perioperative hemostasis, alogenated cardioprotection, preventing perioperative mortality and treatment of perioperative acute renal failure and organ damage in the critically ill, sepsis in intensive care.

In addition to prizes and awards in the medical field and institutional positions, he is awarded the title of Knight of Merit of the Italian Republic and of Commander by the Presidents of the Italian Republic Carlo Azeglio Ciampi and Giorgio Napolitano.

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University of Milan

Degree in Medicine and Surgery - 1983

University of Milan

Specialization in Anaesthesia and Resuscitation – 1986

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Professor Alberto Zangrillo is among the top ten world leading physicians in the world (last two years) for the number of publications in the field of "anaesthesia" and "intensive care" (source: Scopus), the author of more than 800 publications, of which more than 400 in international indexed journals (cited more than 10,000 times, Hindex 50) including randomised studies in The New England Journal of Medicine, JAMA, Circulation and British Medical Journal.

He is the author of 40 papers (monographs and book chapters) and editor-in-chief of Heart Lung and Vessels (indexed in pubmed), editorial board member of Advances in Medicine and grant evaluator for international sponsoring organisations (including the Swiss National Science Foundation, 2009-2015).

Latest publications

Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery.
N Engl J Med. 2019;380(13):1214-1225.
Landoni G, Lomivorotov VV, Nigro Neto C, Monaco F, Pasyuga VV, Bradic N, Lembo R, Gazivoda G, Likhvantsev VV, Lei C, Lozovskiy A, Di Tomasso N, Bukamal NAR, Silva FS, Bautin AE, Ma J, Crivellari M, Farag AMGA, Uvaliev NS, Carollo C, Pieri M, Kunstýř J, Wang CY, Belletti A, Hajjar LA, Grigoryev EV, Agrò FE, Riha H, El-Tahan MR, Scandroglio AM, Elnakera AM, Baiocchi M, Navalesi P, Shmyrev VA, Severi
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Levosimendan for Hemodynamic Support after Cardiac Surgery.
N Engl J Med. 2017;376(21):2021-2031.
Landoni G, Lomivorotov VV, Alvaro G, Lobreglio R, Pisano A, Guarracino F, Calabrò MG, Grigoryev EV, Likhvantsev VV, Salgado-Filho MF, Bianchi A, Pasyuga VV, Baiocchi M, Pappalardo F, Monaco F, Boboshko VA, Abubakirov MN, Amantea B, Lembo R, Brazzi L, Verniero L, Bertini P, Scandroglio AM, Bove T, Belletti A, Michienzi MG, Shukevich DL, Zabelina TS, Bellomo R, Zangrillo A; CHEETAH Study Group.
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Venoarterial Extracorporeal Membrane Oxygenation Support in Lung Cancer Resection
Ann Thorac Surg. 2022 Mar;113(3):e191-e193. doi: 10.1016/j.athoracsur.2021.05.040.
Novellis P, Monaco F, Landoni G, Rossetti F, Carretta A, Gregorc V, Zangrillo A, Veronesi G.
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Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial
JAMA. 2014 Dec 3;312(21):2244-53.
Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F, Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M, Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, Verdecchia C, Dal Checco E, Cariello C, Faita L, Baldassarri R, Scandroglio AM, Saleh O, Lembo R, Calabrò MG, Bellomo R, Landoni G.
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Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial
BMJ. 2011 Oct 19;343:d5701
Crescenti A, Borghi G, Bignami E, Bertarelli G, Landoni G, Casiraghi GM, Briganti A, Montorsi F, Rigatti P, Zangrillo A
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Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: a prospective, double-blind, randomized clinical trial
Circulation. 2005 Jun 21;111(24):3230-5
Bove T, Landoni G, Calabrò MG, Aletti G, Marino G, Cerchierini E, Crescenzi G, Zangrillo A
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Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit.
JAMA. 2020 Jun 9;323(22):2338-2340. doi: 10.1001/jama.2020.7861.PMID: 32412606
Sartini C, Tresoldi M, Scarpellini P, Tettamanti A, Carcò F, Landoni G, Zangrillo A.
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Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis.
Crit Care Resusc. 2020 Apr 15;22(2):95-97. Online ahead of print.PMID: 32294809
Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeri A, Peccatori J, D'Angelo A, De Cobelli F, Rovere-Querini P, Tresoldi M, Dagna L, Zangrillo A.
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Extracorporeal membrane oxygenation to resuscitate a 14-year-old boy after 43min drowning.
Med Intensiva. 2018;42(8):509-510.
Scandroglio AM, Bove T, Calabrò MG, Votta CD, Pappalardo F, Giacomello R, Landoni G, Zangrillo A.
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Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.
COVID-19 Lombardy ICU Network.JAMA. 2020 Apr 28;323(16):1574-1581. doi: 10.1001/jama.2020.5394.PMID: 32250385
Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G, Latronico N, Lorini L, Merler S, Natalini G, Piatti A, Ranieri MV, Scandroglio AM, Storti E, Cecconi M, Pesenti A
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Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: facing the COVID-19 pandemic emergency.
Crit Care Resusc. 2020 Apr 1;22(2):91-94. Online ahead of print.PMID: 32227819
Zangrillo A, Beretta L, Silvani P, Colombo S, Scandroglio AM, Dell’Acqua A, Fominskiy E, Landoni G, Monti G, Azzolini ML, Monaco F, Oriani A, Belletti A, Sartorelli M, Pallanch O, Saleh O, Sartini C, Nardelli P, Lombardi G, Morselli F, Scquizzato T, Frontera A, Ruggeri A, Scotti R, Assanelli A, Dagna L, Rovere-Querini P, Castagna A, Scarpellini P, Di Napoli D, Ambrosio A, Ciceri F, Tresoldi M.
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Extracorporeal Membrane Oxygenation: Beyond Cardiac Surgery and Intensive Care Unit: Unconventional Uses and Future Perspectives.
J Cardiothorac Vasc Anesth. 2018;32(4):1955-1970.
Monaco F, Belletti A, Bove T, Landoni G, Zangrillo A.
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Nonsurgical Strategies to Reduce Mortality in Patients Undergoing Cardiac Surgery: An Updated Consensus Process.
J Cardiothorac Vasc Anesth. 2018;32(1):225-235.
Landoni G, Lomivorotov V, Silvetti S, Nigro Neto C, Pisano A, Alvaro G, Hajjar LA, Paternoster G, Riha H, Monaco F, Szekely A, Lembo R, Aslan NA, Affronti G, Likhvantsev V, Amarelli C, Fominskiy E, Baiardo Redaelli M, Putzu A, Baiocchi M, Ma J, Bono G, Camarda V, Covello RD, Di Tomasso N, Labonia M, Leggieri C, Lobreglio R, Monti G, Mura P, Scandroglio AM, Pasero D, Turi S, Roasio A, Votta CD, Sap
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A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality.
J Cardiothorac Vasc Anesth. 2019;33(5):1430-1439.
Sartini C, Lomivorotov V, Pieri M, Delgado JCL, Baiardo Redaelli M, Hajjar L, Pisano A, Likhvantsev V, Fominskiy E, Bradic N, Cabrini L, Novikov M, Avancini D, Riha H, Lembo R, Gazivoda G, Paternoster G, Wang C, Tamà S, Alvaro G, Wang CY, Roasio A, Ruggeri L, Yong CY, Pasero D, Severi L, Pasin L, Mancino G, Mura P, Musu M, Spadaro S, Conte M, Lobreglio R, Silvetti S, Votta CD, Belletti A, Di Fraja
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Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study.
Lancet Rheumatol. 2020 Jun;2(6):e325-e331. doi: 10.1016/S2665-9913(20)30127-2. Epub 2020 May 7.
Cavalli G, De Luca G, Campochiaro C, Della-Torre E, Ripa M, Canetti D, Oltolini C, Castiglioni B, Tassan Din C, Boffini N, Tomelleri A, Farina N, Ruggeri A, Rovere-Querini P, Di Lucca G, Martinenghi S, Scotti R, Tresoldi M, Ciceri F, Landoni G, Zangrillo A, Scarpellini P, Dagna L.
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