Alberto Zangrillo

Specialty:

Cardiovascular Anesthesia and Intensive Care Cardiovascular Diseases

Profession:

Anesthesiologist and Intensivist

Location:

Department of Cardiothoracic Anesthesia and Intensive Care @ Ospedale San Raffaele Department of General Intensive Care @ Ospedale San Raffaele

Languages:

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Biography

Professor Alberto Zangrillo is the head of the General Anesthesia and Intensive Care Unit, Cardio-Thoraco-Vascular, and the Single Area of Cardiac Intensive Care and Cardiothoracic Surgery, Clinical Area Manager at IRCCS Ospedale San Raffaele in Milan, and collaborates with the Casa di Cura La Madonnina.

At the Vita-Salute San Raffaele University, he holds the positions of Pro-Rector for Clinical Activities and Full Professor of Anesthesia and Intensive Care.

His academic journey began at the University of Milan, where he graduated in Medicine and Surgery in 1983, specializing in Anesthesia and Intensive Care three years later, and then continued at significant European centers such as Queen Charlotte Hospital in London, Hospital de la Santa Creu Pau in Barcelona, the Cardio-thoracic Centre in Monte Carlo, Hetzer Deutsches Herzzentrum in Berlin, and Ospedale San Raffaele.

Professor Alberto Zangrillo is one of the top ten doctors in the world in recent years, in terms of publications in the fields of “anesthesia” and “intensive care” (source: Scopus), with over 800 publications, more than 500 of which are indexed in international journals (cited more than 21,000 times, H-index 67), including randomized studies published in The New England Journal of Medicine, JAMA, Circulation, and the British Medical Journal.

He has won several research grants, including the Ministry of Health’s Finalized Research Grant, an AIFA Independent Research Grant on drugs in 2012, and a Capital Account Grant in the same year (as well as other grants and projects funded by the Lombardy Region). As Principal Investigator, he often participates in 48 randomized research protocols approved by the Ethics Committee of Ospedale San Raffaele.

In research, among many pursued lines, the main ones include advanced circulatory and ventilation support (ECMO, VAD, artificial heart), acute heart failure treatment, non-invasive ventilation (in intensive care and general wards), alternative anticoagulant therapies in intensive care, optimization of perioperative hemostasis, cardioprotection from halogenated agents, prevention of perioperative mortality, treatment of perioperative acute myocardial infarction, prevention and treatment of perioperative acute renal failure and critical patient organ damage, and sepsis in intensive care.

In addition to medical awards and institutional roles, he has been honored with the title of Knight of the Order of Merit of the Italian Republic and Commander by Presidents Carlo Azeglio Ciampi and Giorgio Napolitano.

Education

University of Milan
Degree in Medicine and Surgery - 1983

University of Milan
Specialization in Anaesthesia and Resuscitation - 1986

Multimedia gallery

Continuous or intermittent administration of antibiotics does not reduce the growth of new resistant bacteria

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Publications

Professor Alberto Zangrillo is among the top ten world leading physicians in the world (last two years) for the number of publications in the field of "anaesthesia" and "intensive care" (source: Scopus), the author of more than 800 publications, of which more than 400 in international indexed journals (cited more than 10,000 times, Hindex 50) including randomised studies in The New England Journal of Medicine, JAMA, Circulation and British Medical Journal.

He is the author of 40 papers (monographs and book chapters) and editor-in-chief of Heart Lung and Vessels (indexed in pubmed), editorial board member of Advances in Medicine and grant evaluator for international sponsoring organisations (including the Swiss National Science Foundation, 2009-2015).

Latest publications

Volatile Anesthetics versus Total Intravenous Anesthesia for Cardiac Surgery.

N Engl J Med. 2019;380(13):1214-1225.

Landoni G, Lomivorotov VV, Nigro Neto C, Monaco F, Pasyuga VV, Bradic N, Lembo R, Gazivoda G, Likhvantsev VV, Lei C, Lozovskiy A, Di Tomasso N, Bukamal NAR, Silva FS, Bautin AE, Ma J, Crivellari M, Farag AMGA, Uvaliev NS, Carollo C, Pieri M, Kunstýř J, Wang CY, Belletti A, Hajjar LA, Grigoryev EV, Agrò FE, Riha H, El-Tahan MR, Scandroglio AM, Elnakera AM, Baiocchi M, Navalesi P, Shmyrev VA, Severi

Levosimendan for Hemodynamic Support after Cardiac Surgery.

N Engl J Med. 2017;376(21):2021-2031.

Landoni G, Lomivorotov VV, Alvaro G, Lobreglio R, Pisano A, Guarracino F, Calabrò MG, Grigoryev EV, Likhvantsev VV, Salgado-Filho MF, Bianchi A, Pasyuga VV, Baiocchi M, Pappalardo F, Monaco F, Boboshko VA, Abubakirov MN, Amantea B, Lembo R, Brazzi L, Verniero L, Bertini P, Scandroglio AM, Bove T, Belletti A, Michienzi MG, Shukevich DL, Zabelina TS, Bellomo R, Zangrillo A; CHEETAH Study Group.

Venoarterial Extracorporeal Membrane Oxygenation Support in Lung Cancer Resection

Ann Thorac Surg. 2022 Mar;113(3):e191-e193. doi: 10.1016/j.athoracsur.2021.05.040.

Novellis P, Monaco F, Landoni G, Rossetti F, Carretta A, Gregorc V, Zangrillo A, Veronesi G.

Effect of fenoldopam on use of renal replacement therapy among patients with acute kidney injury after cardiac surgery: a randomized clinical trial

JAMA. 2014 Dec 3;312(21):2244-53.

Bove T, Zangrillo A, Guarracino F, Alvaro G, Persi B, Maglioni E, Galdieri N, Comis M, Caramelli F, Pasero DC, Pala G, Renzini M, Conte M, Paternoster G, Martinez B, Pinelli F, Frontini M, Zucchetti MC, Pappalardo F, Amantea B, Camata A, Pisano A, Verdecchia C, Dal Checco E, Cariello C, Faita L, Baldassarri R, Scandroglio AM, Saleh O, Lembo R, Calabrò MG, Bellomo R, Landoni G.

Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial

BMJ. 2011 Oct 19;343:d5701

Crescenti A, Borghi G, Bignami E, Bertarelli G, Landoni G, Casiraghi GM, Briganti A, Montorsi F, Rigatti P, Zangrillo A

Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: a prospective, double-blind, randomized clinical trial

Circulation. 2005 Jun 21;111(24):3230-5

Bove T, Landoni G, Calabrò MG, Aletti G, Marino G, Cerchierini E, Crescenzi G, Zangrillo A

Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit.

JAMA. 2020 Jun 9;323(22):2338-2340. doi: 10.1001/jama.2020.7861.PMID: 32412606

Sartini C, Tresoldi M, Scarpellini P, Tettamanti A, Carcò F, Landoni G, Zangrillo A.

Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis.

Crit Care Resusc. 2020 Apr 15;22(2):95-97. Online ahead of print.PMID: 32294809

Ciceri F, Beretta L, Scandroglio AM, Colombo S, Landoni G, Ruggeri A, Peccatori J, D'Angelo A, De Cobelli F, Rovere-Querini P, Tresoldi M, Dagna L, Zangrillo A.

Extracorporeal membrane oxygenation to resuscitate a 14-year-old boy after 43min drowning.

Med Intensiva. 2018;42(8):509-510.

Scandroglio AM, Bove T, Calabrò MG, Votta CD, Pappalardo F, Giacomello R, Landoni G, Zangrillo A.

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy.

COVID-19 Lombardy ICU Network.JAMA. 2020 Apr 28;323(16):1574-1581. doi: 10.1001/jama.2020.5394.PMID: 32250385

Grasselli G, Zangrillo A, Zanella A, Antonelli M, Cabrini L, Castelli A, Cereda D, Coluccello A, Foti G, Fumagalli R, Iotti G, Latronico N, Lorini L, Merler S, Natalini G, Piatti A, Ranieri MV, Scandroglio AM, Storti E, Cecconi M, Pesenti A

Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: facing the COVID-19 pandemic emergency.

Crit Care Resusc. 2020 Apr 1;22(2):91-94. Online ahead of print.PMID: 32227819

Zangrillo A, Beretta L, Silvani P, Colombo S, Scandroglio AM, Dell’Acqua A, Fominskiy E, Landoni G, Monti G, Azzolini ML, Monaco F, Oriani A, Belletti A, Sartorelli M, Pallanch O, Saleh O, Sartini C, Nardelli P, Lombardi G, Morselli F, Scquizzato T, Frontera A, Ruggeri A, Scotti R, Assanelli A, Dagna L, Rovere-Querini P, Castagna A, Scarpellini P, Di Napoli D, Ambrosio A, Ciceri F, Tresoldi M.

Extracorporeal Membrane Oxygenation: Beyond Cardiac Surgery and Intensive Care Unit: Unconventional Uses and Future Perspectives.

J Cardiothorac Vasc Anesth. 2018;32(4):1955-1970.

Monaco F, Belletti A, Bove T, Landoni G, Zangrillo A.

Nonsurgical Strategies to Reduce Mortality in Patients Undergoing Cardiac Surgery: An Updated Consensus Process.

J Cardiothorac Vasc Anesth. 2018;32(1):225-235.

Landoni G, Lomivorotov V, Silvetti S, Nigro Neto C, Pisano A, Alvaro G, Hajjar LA, Paternoster G, Riha H, Monaco F, Szekely A, Lembo R, Aslan NA, Affronti G, Likhvantsev V, Amarelli C, Fominskiy E, Baiardo Redaelli M, Putzu A, Baiocchi M, Ma J, Bono G, Camarda V, Covello RD, Di Tomasso N, Labonia M, Leggieri C, Lobreglio R, Monti G, Mura P, Scandroglio AM, Pasero D, Turi S, Roasio A, Votta CD, Sap

A Systematic Review and International Web-Based Survey of Randomized Controlled Trials in the Perioperative and Critical Care Setting: Interventions Reducing Mortality.

J Cardiothorac Vasc Anesth. 2019;33(5):1430-1439.

Sartini C, Lomivorotov V, Pieri M, Delgado JCL, Baiardo Redaelli M, Hajjar L, Pisano A, Likhvantsev V, Fominskiy E, Bradic N, Cabrini L, Novikov M, Avancini D, Riha H, Lembo R, Gazivoda G, Paternoster G, Wang C, Tamà S, Alvaro G, Wang CY, Roasio A, Ruggeri L, Yong CY, Pasero D, Severi L, Pasin L, Mancino G, Mura P, Musu M, Spadaro S, Conte M, Lobreglio R, Silvetti S, Votta CD, Belletti A, Di Fraja

Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study.

Lancet Rheumatol. 2020 Jun;2(6):e325-e331. doi: 10.1016/S2665-9913(20)30127-2. Epub 2020 May 7.

Cavalli G, De Luca G, Campochiaro C, Della-Torre E, Ripa M, Canetti D, Oltolini C, Castiglioni B, Tassan Din C, Boffini N, Tomelleri A, Farina N, Ruggeri A, Rovere-Querini P, Di Lucca G, Martinenghi S, Scotti R, Tresoldi M, Ciceri F, Landoni G, Zangrillo A, Scarpellini P, Dagna L.

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