Paolo Silvani

Profession:
Anesthesiologist and Intensivist
Languages:
EN
IT

Biography

Dr. Paolo Silvani is the coordinator of the Department of Anesthesiology and Emergency Intensive Care and is responsible for the Department of Anesthesiology in the Obstetrics and Anesthesiology Department of the IRCCS Ospedale San Raffaele under the supervision of Professor Alberto Zangrillo.

He graduated from the Faculty of Medicine and Surgery in 1986 at the University of Milan, where he received a specialization in anesthesia and intensive care in 1989.

Dr. Silvani is mainly engaged in clinical activities for anesthesia and resuscitation in an emergency situation. He deals with anesthesia of patients in the obstetric department and is a pediatric resuscitator in the pediatric department of immunohematology and pediatric bone marrow transplantation.

His research activities focus on research protocols and clinical trials for immunohematology gene therapy and pediatric bone marrow transplantation. His Hirsch Index is 11.

Education

University of Milan
Degree of Doctor of Medicine and Surgery — 1986

University of Milan
Specialization in Anesthesiology and Intensive Care — 1989

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Publications

Latest publications

Bone marrow harvesting from paediatric patients undergoing haematopoietic stem cell gene therapy.
Bone Marrow Transplant. 2019 May 31. doi: 10.1038/s41409-019-0573-6
Tucci F, Frittoli M, Barzaghi F, Calbi V, Migliavacca M, Ferrua F, Fumagalli F, Lorioli L, Castagnaro L, Facchini M, Fossati C, Zancan S, Massariello P, Manfredini M, Consiglieri G, Canarutto D, Recupero S, Calzatini F, Casiraghi M, Darin S, Antonioli G, Miniero R, Fiori R, Silvani P, Zambelli M, Marktel S, Gattillo S, Milani R, Santoleri L, Ciceri F, Biffi A, Cicalese MP, Bernardo ME, Aiuti A
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Lentiviral haemopoietic stem/progenitor cell gene therapy for treatment of Wiskott-Aldrich syndrome: interim results of a non-randomised, open-label, phase 1/2 clinical study.
Lancet Haematol. 2019 May;6(5):e239-e253. doi:10.1016/S2352-3026(19)30021-3. Epub 2019 Apr 10
Barzaghi F, Migliavacca M, Bernardo ME, Calbi V, Assanelli AA, Facchini M, Fossati C, Albertazzi E, Scaramuzza S, Brigida I, Scala S, Basso-Ricci L, Pajno R, Casiraghi M, Canarutto D, Salerio FA, Albert MH, Bartoli A, Wolf HM, Fiori R, Silvani P, Gattillo S, Villa A, Biasco L, Dott C, Culme- Seymour EJ, van Rossem K, Atkinson G, Valsecchi MG, Roncarolo MG, Ciceri F, Naldini L, Aiuti A
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Use of Defibrotide to help prevent post-transplant endothelial injury in a genetically predisposed infant with metachromatic leukodystrophy undergoing hematopoietic stem cell gene therapy.
Bone Marrow Transplant. 2018 Jul;53(7):913-917. doi:10.1038/s41409-017-0085-1. Epub 2018 Jan 29
Calbi V, Fumagalli F, Consiglieri G, Penati R, Acquati S, Redaelli D, Attanasio V, Marcella F, Cicalese MP, Migliavacca M, Barzaghi F, Ferrua F, Assanelli A, Silvani P, Zoccolillo M, Chidini G, Chiesa R, Arora R, Ciotti F, Sarzana M, Antonioli G, Baldoli C, Morena F, Martino S, Ardissino GL, Sora MGN, Naldini L, Ciceri F, Aiuti A, Bernardo ME.
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The effect of vasoactive drugs on mortality in patients with severe sepsis and septic shock. A network meta-analysis of randomized trials.
Crit Care. 2017 Feb;37:91-98. doi:10.1016/j.jcrc.2016.08.010. Epub 2016 Aug 13.
Belletti A, Benedetto U, Biondi-Zoccai G, Leggieri C, Silvani P, Angelini GD, Zangrillo A, Landoni G.
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Lentiviral haemopoietic stem-cell gene therapy in earlyonset metachromatic leukodystrophy: an ad-hoc analysis of a non-randomised, open-label, phase 1/2 trial.
Lancet. 2016 Jul 30;388(10043):476-87. doi: 10.1016/S0140-6736(16)30374-9. Epub 2016 Jun 8
Sessa M, Lorioli L, Fumagalli F, Acquati S, Redaelli D, Baldoli C, Canale S, Lopez ID, Morena F, Calabria A, Fiori R, Silvani P, Rancoita PM, Gabaldo M, Benedicenti F, Antonioli G, Assanelli A, Cicalese MP, Del Carro U, Sora MG, Martino S, Quattrini A, Montini E, Di Serio C, Ciceri F, Roncarolo MG, Aiuti A, Naldini L, Biffi A.
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Pioglitazone as a novel therapeutic approach in chronic granulomatous disease.
J Allergy Clin Immunol. 2016 Jun;137(6):1913-1915.e2. doi:10.1016/j.jaci.2016.01.033. Epub 2016 Apr 4.
Migliavacca M, Assanelli A, Ferrua F, Cicalese MP, Biffi A, Frittoli M, Silvani P, Chidini G, Calderini E, Mandelli A, Camporesi A, Milani R, Farinelli G, Nicoletti R, Ciceri F, Aiuti A, Bernardo ME
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Abnormalities of acid-base balance and predisposition to metabolic acidosis in Metachromatic Leukodystrophy patients.
Mol Genet Metab. 2015 May;115(1):48-52. doi:10.1016/j.ymgme.2015.02.009. Epub 2015 Mar 6
Lorioli L, Cicalese MP, Silvani P, Assanelli A, Salvo I, Mandelli A, Fumagalli F, Fiori R, Ciceri F, Aiuti A, Sessa M, Roncarolo MG, Lanzani C, Biffi A
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A systematic review on levosimendan in paediatric patients.
Curr Vasc Pharmacol. 2015;13(1):128-33.
Silvetti S, Silvani P, Azzolini ML, Dossi R, Landoni G, Zangrillo A.
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Noninvasive ventilation outside the intensive care unit from the patient point of view: a pilot study.
Respir Care. 2012 May;57(5):704-9. doi:10.4187/respcare.01474. Epub 2011 Dec 6
Cabrini L, Moizo E, Nicelli E, Licini G, Turi S, Landoni G, Silvani P, Zangrillo A
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Incidence of and mortality due to sepsis, severe sepsis and septic shock in Italian Pediatric Intensive Care Units: a prospective national survey.
Intensive Care Med. 2008 Sep;34(9):1690-7. doi:10.1007/s00134-008-1148-y. Epub 2008 May 24
Wolfler A, Silvani P, Musicco M, Antonelli M, Salvo I; Italian Pediatric Sepsis Study (SISPe) group
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Pediatric Index of Mortality 2 score in Italy: a multicenter, prospective, observational study.
Intensive Care Med. 2007 Aug;33(8):1407-13. Epub 2007 Jun 5.
Wolfler A, Silvani P, Musicco M, Salvo I; Italian Pediatric Sepsis Study (SISPe) Group
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Drug-induced pulmonary hypertension in newborns: a review.
Curr Vasc Pharmacol. 2007 Apr;5(2):129-33. Review
Silvani P, Camporesi A.
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Caudal anesthesia in pediatrics: an update
Minerva Anestesiol. 2006 Jun;72(6):453-9. Review
Silvani P, Camporesi A, Agostino MR, Salvo I.
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A case of severe diazoxide toxicity.
Paediatr Anaesth. 2004 Jul;14(7):607-9.
Silvani P, Camporesi A, Mandelli A, Wolfler A, Salvo I.
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Emergency endovascular treatment of a life-threatening hemorrhage from traumatic rupture of the left extracranial vertebral artery.
Intensive Care Med. 1999 Oct;25(10):1177-9.
Simionato F, Righi C, Silvani P, Torri G, Scotti G
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