Paolo Scarpellini

Infectious disease specialist


Dr. Paolo Scarpellini is an infectious disease specialist at the Infectious Diseases Department of the IRCCS Ospedale San Raffaele Turro under the supervision of Professor Antonella Castagna.

After graduating from the Faculty of Medicine and Surgery of the University of Milan in 1987, he received a specialization in infectious diseases at the same university in 1991. He completed his studies in microbiology and virology at the same university in 1997.

Clinically, Dr. Scarpellini leads the Infectious Diseases Advisory Department, consisting of 4 specialists and 2 PhD students who work in various departments of the internal medicine and surgical department of the hospital, which require about 5,000 consultations per year.

In the past, he also acted as coordinator and manager of activities related to routine hospitalization of the 35-bed Infectious Diseases Unit.

Since 1995, he has also been a member of the Committee for Infection Control in Hospitals (CIO) task force, where he is mainly involved in antibiotic control policy in the hospital through continuous training of medical and nursing staff, and the development and implementation of protocols for controlling hospital consumption of antibiotics.

Carries out outpatient activities (both industry and staff), dealing, in particular: HIV infection, mycobacterial infections (atypical mycobacteriosis and tuberculosis), infections of the osteoarticular and genitourinary systems, infections, and immunosuppression.

Finally, he works as an infectious disease consultant at other Gruppo San Donato institutions and at the Istituto Clinico Città Studi in Milan.

As for scientific activity, the doctor has always been engaged in infectious research.

At the Ospedale San Raffaele, he devoted himself to developing molecular biology methodologies for the rapid diagnosis of mycobacterial diseases. In particular, he independently optimized the methods of the nest polymerase chain reaction for the diagnosis and therapeutic monitoring of tuberculosis disease. He collaborated with other researchers in optimizing methods for determining in vitro sensitization to specific antigens of M.tuberculosis species (ELISPOT-TB for ESAT-6 and CFP-10).

The doctor has been involved in several research projects: from 1995 to 1998 he was the leader of a research project within the National TB Project, Istituto Superiore di Sanità Rome; he also directed a small department of operational research at the hospital. Since May 2006 he has been the owner of an inter-company project in San Raffaele funded by the region of Lombardy (Pharmacological Surveillance Projects) to study and optimize preoperative antibiotic prophylaxis.

He has also collaborated on research to innovate the use of new antibacterial molecules.

Finally, in 2020, he actively collaborated in research on the epidemiology, pathogenesis, and treatment of Sars-Cov-2.

He is the author and co-author of several scientific articles published in international journals and book chapters. He constantly participates as a speaker at international industry congresses and conferences.

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Latest publications

Respiratory Parameters in Patients With COVID-19 After Using Noninvasive Ventilation in the Prone Position Outside the Intensive Care Unit
JAMA. 2020 Jun 9;323(22):2338-2340. doi: 10.1001/jama.2020.7861. PMID: 32412606; PMCID: PMC7229533.
Sartini C, Tresoldi M, Scarpellini P, Tettamanti A, Carcò F, Landoni G, Zangrillo A.
Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases
Eur Respir J. 2020 Jul 9;56(1):2001398. doi: 10.1183/13993003.01398-2020. PMID: 32457198; PMCID: PMC7251245.
Tadolini M, Codecasa LR, García-García JM, Blanc FX, Borisov S, Alffenaar JW, Andréjak C, Bachez P, Bart PA, Belilovski E, Cardoso-Landivar J, Centis R, D'Ambrosio L, Luiza De Souza-Galvão M, Dominguez-Castellano A, Dourmane S, Fréchet Jachym M, Froissart A, Giacomet V, Goletti D, Grard S, Gualano G, Izadifar A, Le Du D, Marín Royo M, Mazza-Stalder J, Motta I, Ong CWM, Palmieri F, Rivière F, Rodri
Early predictors of clinical outcomes of COVID-19 outbreak in Milan, Italy.
Clin Immunol 2020 Aug;217:108509. doi: 10.1016/j.clim.2020.108509. Epub 2020 Jun 12. PMID: 32535188; PMCID: PMC7289745.
Ciceri F, Castagna A, Rovere-Querini P, De Cobelli F, Ruggeri A, Galli L, Conte C, De Lorenzo R, Poli A, Ambrosio A, Signorelli C, Bossi E, Fazio M, Tresoldi C, Colombo S, Monti G, Fominskiy E, Franchini S, Spessot M, Martinenghi C, Carlucci M, Beretta L, Scandroglio AM, Clementi M, Locatelli M, Tresoldi M, Scarpellini P, Martino G, Bosi E, Dagna L, Lazzarin A, Landoni G, Zangrillo A.
Interleukin-1 blockade with high-dose anakinra in patients with COVID-19, acute respiratory distress syndrome, and hyperinflammation: a retrospective cohort study
Lancet Rheumatol. 2020 Jun;2(6):e325-e331. doi: 10.1016/S2665-9913(20)30127-2. Epub 2020 May 7. PMID: 32501454; PMCID: PMC7252085.
Cavalli G, De Luca G, Campochiaro C, Della-Torre E, Ripa M, Canetti D, Oltolini C, Castiglioni B, Tassan Din C, Boffini N, Tomelleri A, Farina N, Ruggeri A, Rovere-Querini P, Di Lucca G, Martinenghi S, Scotti R, Tresoldi M, Ciceri F, Landoni G, Zangrillo A, Scarpellini P, Dagna L.
Pulmonary hypertension and right ventricular involvement in hospitalised patients with COVID-19. Heart
2020 Sep;106(17):1324-1331. doi:10.1136/heartjnl-2020-317355. Epub 2020 Jul 16. PMID: 32675217; PMCID: PMC7476272.
Pagnesi M, Baldetti L, Beneduce A, Calvo F, Gramegna M, Pazzanese V, Ingallina G, Napolano A, Finazzi R, Ruggeri A, Ajello S, Melisurgo G, Camici PG, Scarpellini P, Tresoldi M, Landoni G, Ciceri F, Scandroglio AM, Agricola E, Cappelletti AM.
Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: facing the COVID-19 pandemic emergency
Crit Care Resusc. 2020 Apr 1;22(2):91-94. Epub ahead of print. PMID: 32227819.
Zangrillo A, Beretta L, Silvani P, Colombo S, Scandroglio AM, Dell’Acqua A, Fominskiy E, Landoni G, Monti G, Azzolini ML, Monaco F, Oriani A, Belletti A, Sartorelli M, Pallanch O, Saleh O, Sartini C, Nardelli P, Lombardi G, Morselli F, Scquizzato T, Frontera A, Ruggeri A, Scotti R, Assanelli A, Dagna L, Rovere- Querini P, Castagna A, Scarpellini P, Di Napoli D, Ambrosio A, Ciceri F, Tresoldi M.
Ceftobiprole for the treatment of infective endocarditis: A case series
J Glob Antimicrob Resist. 2020 Mar;20:56-59. doi: 10.1016/j.jgar.2019.07.020. Epub 2019 Jul 24. PMID: 31351247.
Tascini C, Attanasio V, Ripa M, Carozza A, Pallotto C, Bernardo M, Francisci D, Oltolini C, Palmiero G, Scarpellini P.
Adjuvant role of SeptiFast to improve the diagnosis of sepsis in a large cohort of hematological patients
Bone Marrow Transplant. 2018 Apr;53(4):410-416. doi: 10.1038/s41409-017-0039-7. Epub 2018 Jan 12. PMID: 29330406.
Greco R, Barbanti MC, Mancini N, Crucitti L, Oltolini C, Forcina A, Lorentino F, Vago L, Messina C, Clerici D, Morelli M, Giglio F, Lupo Stanghellini MT, Infurnari L, Carrabba MG, Marktel S, Assanelli A, Scarpellini P, Bernardi M, Peccatori J, Corti C, Clementi M, Ciceri F.
Clostridium difficile PCR Ribotype 018, a Successful Epidemic Genotype
J Clin Microbiol. 2015 Aug;53(8):2575-80. doi: 10.1128/JCM.00533-15. Epub 2015 Jun 3. PMID: 26041894; PMCID: PMC4508423.
Baldan R, Trovato A, Bianchini V, Biancardi A, Cichero P, Mazzotti M, Nizzero P, Moro M, Ossi C, Scarpellini P, Cirillo DM.
COVID-BioB study group. Secondary infections in patients hospitalized with COVID-19: incidence and predictive factors
Clin Microbiol Infect. 2020 Oct 24:S1198-743X(20)30652-2. doi: 10.1016/j.cmi.2020.10.021. Epub ahead of print. PMID: 33223114; PMCID: PMC7584496.
Ripa M, Galli L, Poli A, Oltolini C, Spagnuolo V, Mastrangelo A, Muccini C, Monti G, De Luca G, Landoni G, Dagna L, Clementi M, Rovere Querini P, Ciceri F, Tresoldi M, Lazzarin A, Zangrillo A, Scarpellini P, Castagna A;
Rapid diagnosis of mycobacterial infections and quantitation of Mycobacterium tuberculosis load by two real-time calibrated PCR assays
J Clin Microbiol. 2003 Oct;41(10):4565-72. doi:10.1128/jcm.41.10.4565-4572.2003. PMID: 14532183; PMCID: PMC254334.
Broccolo F, Scarpellini P, Locatelli G, Zingale A, Brambilla AM, Cichero P, Sechi LA, Lazzarin A, Lusso P, Malnati MS.
Selected pool of peptides from ESAT-6 and CFP-10 proteins for detection of Mycobacterium tuberculosis infection
J Clin Microbiol. 2004 Aug;42(8):3469-74. doi:10.1128/JCM.42.8.3469-3474.2004. PMID: 15297485; PMCID: PMC497651.
Scarpellini P, Tasca S, Galli L, Beretta A, Lazzarin A, Fortis C.
Detection of Pneumocystis carinii and characterization of mutations associated with sulfa resistance in bronchoalveolar lavage samples from human immunodeficiency virus-infected subjects
J Clin Microbiol. 2003 Jun;41(6):2709-12. doi: 10.1128/jcm.41.6.2709-2712.2003. PMID: 12791912; PMCID: PMC156552.
Zingale A, Carrera P, Lazzarin A, Scarpellini P.
Direct detection of Helicobacter pylori mutations associated with macrolide resistance in gastric biopsy material taken from human immunodeficiency virus-infected subjects
J Clin Microbiol. 2002 Jun;40(6):2234-7. doi: 10.1128/jcm.40.6.2234-2237.2002. PMID: 12037095; PMCID: PMC130724.
Scarpellini P, Carrera P, Cavallero A, Cernuschi M, Mezzi G, Testoni PA, Zingale A, Lazzarin A.

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