Lina Raffaella Barzaghi



Dr. Lina Raffaella Barzaghi is the head of the Functional Department of Stereotactic Surgery in the Department of Neurosurgery of the IRCCS Ospedale San Raffaele, headed by Professor Pietro Mortini.

After graduating from the Faculty of Medicine and Surgery of the University of Milan in 1998, in 2003 she specialized in neurosurgery at the Vita-Salute San Raffaele University in Milan. In 2019, she received a diploma in stereotactic and functional neurosurgery from the European Society of Stereotactic and Functional Neurosurgery.

Dr. Barzaghi has performed about 1,200 neurosurgical operations as a first surgeon, participated in more than 2,500 operations as a second surgeon, about 500 as a teacher at a specialized school of neurosurgery and about 500 gamma knife procedures. She deals, in particular, with cranial pathology, such as brain tumors (gliomas, ependymomas, neuromas, meningiomas, brain lymphomas, brain metastases), cavernous angiomas, adult hydrocephalus and traumatic brain injuries.

In the field of functional neurosurgery, he deals with motor disorders (essential tremor, Parkinson's disease, dystonia) and facial pain (trigeminal neuralgia, occipital neuralgia, autonomic headaches and craniofacial neuropathic pain) using neuromodulation methods (deep brain stimulation) and/or stereotactic radiosurgery (gamma knife).

In terms of clinical research, she has developed microsurgical methods with intraoperative support for ultrasound, neuronavigation or stereotaxis and neurophysiological monitoring (cortical and subcortical stimulation, micro-recording and deep stimulation) to map brain functions. Then she deepened her knowledge in the field of software for merging anatomical images (ultrasound, high-field MRI and tractography) and functional (functional MRI and neurophysiological monitoring) for three-dimensional planning of surgical strategy and verification of treatment results. These technologies are used in microsurgery of brain tumors or cavernous angiomas, as well as in the treatment of arteriovenous malformations, brain tumors with a gamma knife, or in the planning of stereotactic surgery (biopsy, drainage, insertion of catheters or recording electrodes and deep brain stimulation).

She is a member of international societies such as the European Society of Stereotactic and Functional Neurosurgery (ESSFN), the European Leksell Gamma Knife Society (ELGKS) and the International Radiosurgery Society (ISRS) and national societies such as the Society for Hospital Neurological Sciences (SSS).

Her scientific contribution (Hirsch Index-17): published in indexed international journals such as: Journal of Neurology, Neurosurgery and Psychiatry, Neurosurgery, World Neurosurgery, Neurosurgical Review, Acta Neurochirurgica, American Journal of Pathology, Pituitary, Endocrine, Journal of Neurology, Neurology. Constantly participates as a speaker at national and international scientific congresses.

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University of Milan
Diploma in Medicine and Surgery - 1998

Vita-Salute San Raffaele University
Specialization in neurosurgery-2009

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Latest publications

Safety and efficacy of multisession gamma knife radiosurgery for residual or recurrent pituitary adenomas.
Endocrine. 2019, Feb 23
Albano L, Losa M, Nadin F, Barzaghi LR, Parisi V, Del Vecchio A, Bolognesi A, Mortini P
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Bone resorption in autologous cryopreserved cranioplasty: quantitative evaluation, semiquantitative score and clinical significance.
Acta Neurochir. 2019, Mar; 161 (3):483-491
Barzaghi LR, Parisi V, Gigliotti CR, Giudice L, Snider S, Dell’Acqua A, Del Vecchio A, Mortini P.
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Singol fraction and multisession Gamma Knife radiosurgery for craniopharyngioma.
Pituitary. 2018 Oct;21(5):499-506. doi:10.1007/s11102-018-0903-5
Losa M, Pieri V, Bailo M, Gagliardi F, Barzaghi LR, Gioia L, Del Vecchio A, Bolognesi A, Mortini P.
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Usefulness of Ultrasound-Guided Microsurgery in Cavernous Angioma Removal.
World Neurosurg 2018 Aug;116:e414-e420. doi: 10.1016/j.wneu.2018.04.217
Barzaghi LR, Capitanio JF, Giudice L, Panni P, Acerno S, Mortini P.
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Pediatric Pituitary Adenomas: Early and Long- Term Surgical Outcome in a Series of 85 Consecutive Patients.
Neurosurgery. 2018 May 22. doi: 10.1093/neuros/nyy2042018
Barzaghi LR, Losa M, Capitanio JF, Albano L, Weber G, Mortini P.
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Microsurgical therapy of pituitary adenomas.
Endocrine 2018; 59:72-81
Mortini P, Barzaghi LR, Albano L, Panni P, Losa M:
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Treatment of empty sella associated with visual impairment: a systematic review of chiasmapexy techniques.
Pituitary 2018: 21:98-106
Barzaghi LR, Donofrio C, Panni P, Losa M, Mortini P
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Transfrontal-Sinus-Subcranial Approach to Olfactory Groove Meningiomas: Surgical Results, Clinical and Functional Outcome in a Consecutive Series of 21 Patients
World Neurosurg 2017; 101: 315-324
Barzaghi LR, Spina A, Gagliardi F, Boari N, Mortini P
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Prognostic factors of visual field improvement after trans-sphenoidal approach for pituitary macroadenomas: review of the literature and analysis by quantitative method
Nerosurg Rev 2012; 35:369-379
Barzaghi LR, Medone M, Losa M, Bianchi S, Giovanelli M, Mortini P
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Visual out come after fronto-temporo-orbito-zygomatic approach combined with extradural and intradural optic nerve decompression in tuberculum and diaphragma sellae meningiomas.
Clinical Neurology and Neurosurgery 2012; 114: 597-606
Mortini P, Barzaghi LR, Serra C, Orlandi V, Bianchi S, Losa M.
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Neurosurgical treatment of craniopharyngioma in adults and children: early and long-term results in a large case series.
J Neurosurg. 2011 May;114(5):1350-9. Epub 2011 Jan 7.
Mortini P, Losa M, Pozzobon G, Barzaghi LR, Riva M, Acerno S, Angius D, Weber G, Chiumello G, Giovanelli M
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Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence.
J Neurosurg. 2008 Mar; 108 (3): 525-32
Losa M, Mortini P, Barzaghi LR, Ribotto P, Terreni MR, Marzoli SB, Pieralli S, Giovanelli M
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Complications of transsphenoidal surgery in patients with pituitary adenoma: experience at a single centre.
Acta Neurochir. 2007 Jul; 149(9): 877-85; discussion 885-6.
Barzaghi LR, Losa M, Giovanelli M, Mortini P.
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Surgical treatment of giant pituitary adenomas: strategies and results in a series of 95 consecutive patients.
Neurosurgery. 2007 Jun; 60 (6): 993-1002; discussion 1003-4
Mortini P, Barzaghi LR, Losa M, Boari N, Giovanelli M;
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