Gabriele Fragasso


Dr Gabriele Fragasso is the head of the Functional Unit of Cardiac Insufficiency of the Operating Unit of Cardiology of IRCCS Ospedale San Raffaele directed by Professor Alberto Margonato.

After graduating in Medicine and Surgery in 1982 from the University of Rome, he specialized in Nuclear Medicine at the Sapienza University of Rome in 1985. Then, he obtained his second specialization in Cardiology in 1990 at the University of Catania. During his studies, he spent time abroad at the Royal Postgraduate Medical School, Hammersmith Hospital, London (now Imperial College), UK.

Over the years, Dr. Gabriele Fragasso has gained extensive experience in both non-invasive and invasive cardiology. In the early years of his practice, he gains extensive experience in right and left heart catheterization procedures, temporary ventricular pacing and pericardiocentesis, and management of acute cardiology patients. In recent years, he has worked mainly in the field of clinical cardiology and echocardiographic imaging, focusing mainly on patients with heart failure. Since 2007, he performs endomyocardial biopsies.

His scientific interests have been directed primarily at the metabolic and functional ties of ischemic heart disease and heart failure. He gives special attention to understanding the pathophysiological mechanisms of myocardial dysfunction.

Recently, his research has focused on assessing cellular, metabolic, and functional adaptation in heart failure of various etiologies, and identifying specific metabolic phenotypes along with potential therapeutic implications. Over the years, Dr. Fragasso has coordinated numerous international clinical research projects in cardiology.

Currently, he is Adjunct Professor of Cardiology at the University Vita-Salute San Raffaele of Milan for the Master of Science in Medicine in English (International Medical Doctor Program).


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La Sapienza University of Rome

Degree in Medicine and Surgery – 1982


La Sapienza University of Rome

Specialization in Nuclear Medicine – 1985


University of Catania

Specialization in Cardiology – 1990

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He is an author of 160 peer-reviewed publications; his H-index is 29. In addition, he is an author and co-author of 250 information materials for international and national scientific congresses. He constantly participates in national and international congresses in respective area. He is a reviewer for the world's leading medical and cardiology journals, including The Lancet, Nature, Circulation, Cochrane Archives, American Journal of Cardiology, and European Heart Journal.

Latest publications

Age-related reduction of myocardial metabolic efficiency: Is it time to routinely measure myocardial metabolism to monitor cardiac health?
Heart 2018;104:88-89
Fragasso G.
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Effects of short-term manipulation of serum FFA concentrations on left ventricular energy metabolism and function in patients with heart failure: no association with circulating bio-markers
Acta Diabetol 2015;52:753-61
Salerno A, Fragasso G, Esposito A, Canu T, Lattuada G, Manzoni G, Del Maschio A, Margonato A, De Cobelli F, Perseghin G
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Prognostic role of stress/rest myocardial perfusion scintigraphy in patients with cardiac syndrome x.
Int J Cardiol 2014; 173: 467–471
Fragasso G, Lauretta L, Busnardo E, Cera M, Godino C, Colombo A, Calori G, Todeschini P, Spinapolice E, Cappelletti A, Gianolli L, Margonato A.
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