Filippo Gagliardi



Dr. Filippo Gagliardi is a neurosurgeon in the Department of Neurosurgery at the IRCCS Ospedale San Raffaele, headed by Professor Pietro Mortini.

After graduating with honors from the Faculty of Medicine and Surgery of the University of Verona in 2006, he majored with honors in neurosurgery at the Vita Salute San Raffaele University of Milan in 2013. He completed his studies in 2016, having defended his doctoral dissertation in the field of neurology at the International Doctoral School of Molecular Medicine of the Vita-Salute University of Milan.

Dr. Gagliardi received the Karl Storz International Prize for research in the field of skull Base surgery (2012). He has also been a research associate in the Department of Neurosurgery at Ludwig Maximilian University (Munich, Germany) and in the Department of Neurosurgery at George Washington University (Washington, DC, USA), with whom he currently continues to collaborate on numerous research projects and periodic internships on site.

In 2011, he passed the written exam in neurosurgery in the "European Association of Neurosurgical Societies". In 2017, he received the national scientific qualification of a second-level neurosurgery teacher.

From a clinical point of view, Dr. Gagliardi mainly deals with brain and spinal cord tumor surgery, stereotaxy, stereotactic radiosurgery, as well as instrumental and minimally invasive spine surgery.

As a researcher, Dr. Gagliardi is actively involved in the development of clinical and preclinical research projects related to the molecular biology of the treatment of brain tumors, the molecular characterization of cancer stem cells and the development of innovative neuroimaging and radiogenomics protocols. Areas of clinical research include the development of new microsurgical methods and technologies for the treatment of brain and skull base tumors, as well as innovative models of neurosurgery training.

He was invited as a member of the scientific committee to numerous international courses and meetings in Europe, the USA and Australia. He has held invited conferences and seminars at Italian and foreign universities, including Macquarie University (Sydney, New South Wales, Australia) and George Washington University (Washington, DC, USA).

He is the author of more than 60 scientific publications in international journals and numerous chapters of books on neurosurgery published by international publishers and online journals. His current Hirsch index is 13. In 2019, he published a book on surgical technique called "Operative cranial neurosurgical anatomy", distributed worldwide by an American publishing house.

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Latest publications

Enhanced SPARCL1 expression in cancer stem cells improves preclinical modeling of glioblastoma by promoting both tumor infiltration and angiogenesis.
Neurobiol Dis. 2020 Feb;134:104705. doi: 10.1016/j.nbd.2019.104705. Epub 2019 Dec 10.
Gagliardi F, Narayanan A, Gallotti AL, Pieri V, Mazzoleni S, Cominelli M, Rezzola S, Corsini M, Brugnara G, Altabella L, Politi LS, Bacigaluppi M, Falini A, Castellano A, Ronca R, Poliani PL, Mortini P, Galli R.
The proneural gene ASCL1 governs the transcriptional subgroup affiliation in glioblastoma stem cells by directly repressing the mesenchymal gene NDRG1.
Cell Death Differ. 2019 Sep;26(9):1813-1831. doi: 10.1038/s41418-018-0248-7. Epub 2018 Dec 11.
Narayanan A, Gagliardi F, Gallotti AL, Mazzoleni S, Cominelli M, Fagnocchi L, Pala M, Piras IS, Zordan P, Moretta N, Tratta E, Brugnara G, Altabella L, Bozzuto G, Gorombei P, Molinari A, Padua RA, Bulfone A, Politi LS, Falini A, Castellano A, Mortini P, Zippo A, Poliani PL, Galli R.
Effectiveness of Gamma Knife Radiosurgery in Improving Psychophysical Performance and Patient's Quality of Life in Idiopathic Trigeminal Neuralgia.
World Neurosurg. 2018 Feb;110:e776-e785. doi: 10.1016/j.wneu.2017.11.096. Epub 2017 Nov 24.
Gagliardi F, Spina A, Bailo M, Boari N, Cavalli A, Franzin A, Fava A, Del Vecchio A, Bolognesi A, Mortini P.
Gamma Knife Radiosurgery for Low-Grade Gliomas: Clinical Results at Long-Term Follow-Up of Tumor Control and Patients' Quality of Life.
World Neurosurg. 2017 May;101:540-553. doi: 10.1016/j.wneu.2017.02.041. Epub 2017 Feb 16.
Gagliardi F, Bailo M, Spina A, Donofrio CA, Boari N, Franzin A, Fava A, Del Vecchio A, Bolognesi A,
Resection of tumors of the third ventricle involving the hypothalamus: effects on body mass index using a dedicated surgical approach.
Endocrine. 2017 Jul;57(1):138-147. doi: 10.1007/s12020-016-1102-7. Epub 2016 Sep 29.
Mortini P, Gagliardi F, Bailo M, Boari N, Castellano A, Falini A, Losa M.
Skull base chordomas: clinical outcome in a consecutive series of 45 patients with long-term follow-up and evaluation of clinical and biological prognostic factors.
J Neurosurg. 2016 Aug;125(2):450-60. doi: 10.3171/2015.6.JNS142370. Epub 2016 Jan 8.
Boari N, Gagliardi F, Cavalli A, Gemma M, Ferrari L, Riva P, Mortini P.
Magnetic resonance imaging as predictor of functional outcome in craniopharyngiomas.
Endocrine. 2016 Jan;51(1):148-62. doi: 10.1007/s12020-015-0683-x. Epub 2015 Jul 16.
Mortini P, Gagliardi F, Bailo M, Spina A, Parlangeli A, Falini A, Losa M.
Gamma Knife radiosurgery for vestibular schwannoma: clinical results at long-term follow-up in a series of 379 patients.
J Neurosurg. 2014 Dec;121 Suppl:123-42. doi: 10.3171/2014.8.GKS141506.
Boari N, Bailo M, Gagliardi F, Franzin A, Gemma M, del Vecchio A, Bolognesi A, Picozzi P, Mortini P.
The role of CXCR4 in highly malignant human gliomas biology: current knowledge and future directions.
Glia. 2014 Jul;62(7):1015-23. doi: 10.1002/glia.22669. Epub 2014 Apr 8.
Gagliardi F, Narayanan A, Reni M, Franzin A, Mazza E, Boari N, Bailo M, Zordan P, Mortini P.
Temporal myofascial segmentation for multilayer reconstruction of middle cranial fossa floor after extradural subtemporal approach to the clival and paraclival region.
Head Neck. 2019 Oct;41(10):3631-3638. doi: 10.1002/hed.25896. Epub 2019 Aug 7.
Gagliardi F, Piloni M, Bailo M, Gragnaniello C, Nocera G, Boari N, Spina A, Caputy AJ, Mortini P.
Transfrontal-Sinus-Subcranial Approach to Olfactory Groove Meningiomas: Surgical Results and Clinical and Functional Outcome in a Consecutive Series of 21 Patients.
World Neurosurg. 2017 May;101:315-324. doi: 10.1016/j.wneu.2017.02.039. Epub 2017 Feb 15.
Barzaghi LR, Spina A, Gagliardi F, Boari N, Mortini P.
Endoscope-Assisted Transmaxillosphenoidal Approach to the Sellar and Parasellar Regions: An Anatomic Study.
World Neurosurg. 2016 Nov;95:246-252. doi: 10.1016/j.wneu.2016.08.034. Epub 2016 Aug 18.
Gagliardi F, Donofrio CA, Spina A, Bailo M, Gragnaniello C, Gallotti AL, Elbabaa SK, Caputy AJ, Mortini P.
Suprasellar granular cell tumor of the neurohypophysis: surgical outcome of a very rare tumor.
Pituitary. 2016 Jun;19(3):277-85. doi: 10.1007/s11102-016-0704-7.
Gagliardi F, Spina A, Barzaghi LR, Bailo M, Losa M, Terreni MR, Mortini P.
Surgical strategies and modern therapeutic options in the treatment of craniopharyngiomas.
Crit Rev Oncol Hematol. 2013 Dec;88(3):514-29. doi: 10.1016/j.critrevonc.2013.07.013. Epub 2013 Aug 7.
Mortini P, Gagliardi F, Boari N, Losa M.
The combined interhemispheric subcommissural translaminaterminalis approach for large craniopharyngiomas.
World Neurosurg. 2013 Jul-Aug;80(1-2):160-6. doi: 10.1016/j.wneu.2012.06.042. Epub 2012 Aug 13.
Mortini P, Gagliardi F, Boari N, Roberti F, Caputy AJ.

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