Enrico Papaleo


Since April 2012, Dr. Enrico Papaleo is head of the Natality Sciences Center of the Unit of Gynecology and Obstetrics of IRCCS San Raffaele Hospital in Milan directed by Professor Massimo Candiani.

After graduating in Medicine and Surgery in 1999 from the University of Milan, he specialized in Gynecology and Obstetrics in 2005 with honors at the University Vita-Salute San Raffaele. In 2005, he began clinical and scientific collaboration at IVI Valencia in the International Department of Reproductive Medicine.

Dr. Papaleo works both at the Natal Science Center where he carries out and coordinates clinical and research activities in the field of reproductive medicine, and in the Department of Gynecology and Obstetrics where he carries out clinical and surgical activities.

The areas of greatest interest of Dr Papaleo in the clinical and scientific fields are female infertility, from causes to treatments, and the methods of medically assisted procreation (PMA). Research activities are mainly focused on the personalization of care in women undergoing treatment for medically assisted reproduction; the study of the correlation between ovarian reserve and ovulation induction (Anti Mullerian Hormone); the relationship between the immune system and implantation failure; endometriosis as a cause of infertility. In the field of gynecologic endocrinology, his interest is focused on the topics of polycystic ovary, insulin resistance and menstrual disorders.

Since 2005, he is a member of ESHRE (European Society of Human Reproduction).

He is the author of more than 50 publications on international scientific journals.

He is a speaker and/or Chairman in over 100 national or international congresses.

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University of Milan

Degree in Medicine and Surgery – 1999

University Vita-Salute San Raffaele

Specialization Gynecology and Obstetrics – 2005

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He is the author of more than 50 publications on international scientific journals.

Latest publications

Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research.
Int J Mol Sci. 2018 Aug 8;19(8)
Cermisoni GC, Alteri A, Corti L, Rabellotti E, Papaleo E, Viganò P, Sanchez AM
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Abnormal sperm concentration and motility as well as advanced paternal age compromise early embryonic development but not pregnancy outcomes: a retrospective study of 1266 ICSI cycles.
J Assist Reprod Genet. 2018 Oct;35(10):1897-1903
Bartolacci A, Pagliardini L, Makieva S, Salonia A, Papaleo E, Viganò P.
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Multifactorial analysis of the stochastic epigenetic variability in cord blood confirmed an impact of common behavioral and environmental factors but not of in vitro conception
Clin Epigenetics. 2018 Jun 8;10:77.
Gentilini D, Somigliana E, Pagliardini L, Rabellotti E, Garagnani P, Bernardinelli L, Papaleo E, Candiani M, Di Blasio AM, Viganò P.
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Excessive fetal growth in frozen embryo transfer: false alarm or clinical concern?
um Reprod Update. 2018 Jul 1;24(4):516-517
Somigliana E, Vanni VS, Busnelli A, Reschini M, Papaleo E, Viganò P
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Assessing the clinical significance of elevated progesterone during controlled ovarian stimulation: the unanswered question about embryo quality.
Hum Reprod. 2018 Jun 1;33(6):1191-1192
Vanni VS, Alleva E, Papaleo E, Candiani M, Somigliana E, Viganò P.
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Human Chorionic Gonadotrophin as a Possible Mediator of Leiomyoma Growth during Pregnancy: Molecular Mechanisms.
Int J Mol Sci. 2017 Sep 20;18(9).
Sarais V, Cermisoni GC, Schimberni M, Alteri A, Papaleo E, Somigliana E, Vigano' P.
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Sleep disturbances and semen quality in an Italian cross sectional study.
Basic Clin Androl. 2017 Aug 21;27:16
Viganò P, Chiaffarino F, Bonzi V, Salonia A, Ricci E, Papaleo E, Mauri PA, Parazzini F.
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Is the oocyte quality affected by endometriosis? A review of the literature.
J Ovarian Res. 2017 Jul 12;10(1):43
Sanchez AM, Vanni VS, Bartiromo L, Papaleo E, Zilberberg E, Candiani M, Orvieto R, Viganò P
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Top quality blastocyst formation rates in relation to progesterone levels on the day of oocyte maturation in GnRH antagonist IVF/ICSI cycles.
PLoS One. 2017 May 17;12(5)
Vanni VS, Somigliana E, Reschini M, Pagliardini L, Marotta E, Faulisi S, Paffoni A, Vigano' P, Vegetti W, Candiani M, Papaleo E.
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Long-acting recombinant follicle-stimulating hormone in random-start ovarian stimulation protocols for fertility preservation in women with cancer.
Acta Obstet Gynecol Scand. 2017 Aug;96(8):949-953
Sarais V, Paffoni A, Pagliardini L, Filippi F, Martinelli F, Mangili G, Candiani M, Papaleo E.
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Advances in improving fertility in women through stem cell-based clinical platforms.
Expert Opin Biol Ther. 2017 May;17(5):585-593
Vanni VS, Viganò P, Papaleo E, Mangili G, Candiani M, Giorgione V
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Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa
Reprod Biomed Online. 2017 Apr;34(4):414-421.
Navas P, Paffoni A, Intra G, González-Utor A, Clavero A, Gonzalvo MC, Díaz R, Peña R, Restelli L, Somigliana E, Papaleo E, Castilla JA, Viganò P.
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Timing should no longer be an obstacle to oocyte cryopreservation in patients with cancer
Tumori. 2017 Mar 24;103(2):182-186
Mangili G, Papaleo E, Sigismondi C, Masciangelo R, Sarais V, Giorgione V, Nale R, Privitera L, Carnelli L, Di Mattei V, Candiani M.
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ESTHER-1 study group. Individualized versus conventional ovarian stimulation for in vitro fertilization: a multicenter, randomized, controlled, assessor-blinded, phase 3 noninferiority trial.
Fertil Steril. 2017 Feb;107(2):387-396.
Nyboe Andersen A, Nelson SM, Fauser BC, García-Velasco JA, Klein BM, Arce JC

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