Piermarco Piatti



Dr. Piermarco Piatti directs the Functional Department of Cardiometabolic and Clinical Trials of the Department of Operative General Medicine with special attention to Diabetes and Metabolic Endocrine Diseases at the IRCCS San Raffaele under the supervision of Professor Emanuele Bosi.

After graduating from the University of Milan in 1981 with a degree in Medicine and Surgery, he specialized at the same institute in diabetology and metabolic diseases in 1985 and then in biochemistry and clinical chemistry. In 2005, he received a Master's Degree in Rehabilitation for Diseases of the Cardiovascular System from the University of Naples Federico II. During his career, Dr. Piatti has spent several periods of research abroad at Newcastle University in England and at the Claude Bernard University of Lyon in France.

The clinical and outpatient activities of Dr. Piermarco Piatti are mainly related to diabetes and dyslipidemia, and he collaborates daily with the departments of cardiology, cardiac surgery, thoracic surgery, vascular surgery, infectious diseases and psychiatry of this institute.

Dr. Piatti was President of the Italian Society of Diabetes, Section of Lombardy, and National Coordinator of the Atherosclerosis and Cardiovascular Diseases Group of the Italian Society of Diabetes.

He conducts experimental clinical trials in the prevention and treatment of diabetes mellitus and cardiovascular disease and is the principal investigator of about 30 sponsored clinical trials relating to the prevention and treatment of diabetes mellitus, dyslipidemia, cardiovascular disease and renal failure.

He is the author and co-author of 200 publications in industry scientific journals and book chapters. His Hirsch Index is 36. Constantly takes part in national and international industry congresses.

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University of Milan
Degree of Doctor of Medicine and Surgery — 1981

University of Milan
Specialization in Diabetology and Diseases Caused by Metabolic Disorders — 1985

University of Milan
Specialization in Biochemistry and Clinical Chemistry — 1990

University of Naples Federico II
Master of Cardiovascular Rehabilitation — 2005

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Latest publications

Decreased Diabetes risk over 9 year after 18 months oral L-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of L-arginine study)
Eur J Nutr, 2017, DOI: 10.1007/s00394-017-1548-2
Lucilla D. Monti, Elena Galluccio, Valentina Villa, Barbara Fontana, Serena Spadoni, Piermarco Piatti.
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Lixilan-O trial investigators. Benefits of LixiLan, a Titratable Fixed-Ratio Combination of Insulin Glargine Plus Lixisenatide, Versus Insulin Glargine and Lixisenatide Monocomponents in Type 2 Diabetes Inadequately Controlled on Oral Agents: The LixiLan-O Randomized Trial.
Diabetes Care. ;39:2026-2035; 2016
Rosenstock J, Aronson R, Grunberger G, Hanefeld M, Piatti P, Serusclat P, Cheng X, Zhou T, Niemoeller E, Souhami E, Davies M
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Pharmacogenetic influence of eNOS gene variant on endothelial and glucose metabolism responses to L-arginine supplementation: Post hoc analysis ofthe L-arginine trial
Metabolism, 64:1582-91; 2015.
Monti LD, Galluccio E, Fontana B, Spadoni S, Comola M, Marrocco Trischitta MM, Chiesa R, Comi G, Bosi E, Piatti P.
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A novel truncated form of eNOS associates with altered vascular function.
Cardiovasc Res. 101:492-502, 2014.
Galluccio E, Cassina L, Russo I, Gelmini F, Setola E, Rampoldi L, Citterio L, Rossodivita A, Kamami M, Colombo A, Alfieri O, Carini M, Bosi E, Trovati M, Piatti P, Monti LD, Casari G
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Smoking is associated with impaired glucose regulation and a decrease in insulin sensitivity and the disposition index in first-degree relatives of type 2 diabetes subjects independently of the presence of metabolic syndrome
Acta Diabetol. 51:793-9, 2014.
Piatti P, Setola E, Galluccio E, Costa S, Fontana B, Stuccillo M, Crippa V, Cappelletti A, Margonato A, Bosi E, Monti LD.
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L-Arginine enriched biscuits improve endothelial function and glucose metabolism: A pilot study in healthy subjects and a cross-over study in subjects with impaired glucose tolerance and metabolic syndrome.
Metabolism. 62:255-64, 2013.
Monti LD, Casiraghi MC, Setola E, Galluccio E, Pagani MA, Quaglia L, Bosi E, Piatti P
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Effect of normalization of fasting glucose by intensified insulin therapy and influence of eNOS polymorphisms on the incidence of restenosis after peripheral angioplasty in patients with type 2 diabetes: a randomized, open-label clinical trial.
Acta Diabetol. 50:373-82, 2013
Piatti PM, Marone E, Mantero M, Setola E, Galluccio E, Lucotti P, Shehaj E, Villa V, Perticone F, Venturini M, Palini A, Airoldi F, Faglia E, Del Maschio A, Colombo A, Chiesa R, Bosi E, Monti LD
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Effects of chronic elevation of atrial natriuretic peptide and free fatty acid levels in the induction of type 2 diabetes mellitus and insulin resistance in patients with mitral valve disease.
Nutr Metab Cardiovasc Dis. 2012 22:58-65, 2012.
Monti LD, Lucotti PC, Setola E, Rossodivita A, Pala MG, Galluccio E, Lacanna G, Castiglioni A, Cannoletta M, Meloni C, Zavaroni I, Bosi E, Alfieri O, Piatti PM
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Effect of a long-term oral l-arginine supplementation on glucose metabolism: a randomized, double-blind, placebo-controlled trial.
Diabetes Obes Metab. 14:893-900, 2012.
Monti LD, Setola E, Lucotti PC, Marrocco-Trischitta MM, Comola M, Glluccio E, Poggi A, Mammì S, Catapano AL, Comi G, Chiesa R, Bosi E, Piatti PM
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Long-term oral L-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients.
Diabetes Care 24: 875-880, 2001
Piatti PM, Monti LD, Valsecchi G, Magni F, Setola E, Marchesi F, Galli-Kienle M, Pozza G, Alberti Kgmm
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Acute Intravenous L-Arginine Infusion Decreases Endothelin-1 Levels and Improves Endothelial Function in Patients with Angina Pectoris and Normal Coronary Arteriograms: Correlation with ADMA Levels
Circulation 107:429-36, 2003
Piatti PM, Fragasso G, Monti LD, Setola E, Lucotti P, Fermo I, Paroni R, Galluccio E, Pozza G, Chierchia S, Margonato A
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Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome
Diabetes 52:1270-5, 2003.
Monti LD, Barlassina C, Citterio L, Galluccio E, Berzuini C, Setola E, Valsecchi G, Lucotti P, Pozza G, Bernardinelli L, Casari G, Piatti PM
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Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting
Circulation 108:2074-2081, 2003.
Piatti PM, Di Mario C, Monti LD, Fragasso G, Sgura F, Caumo A, Setola E, Lucotti P, Galluccio E, Ronchi C, Origgi A, Margonato A, Colombo A
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Hypocaloric high protein diet improves glucose oxidation and spares lean body mass. Comparison with hypocaloric high complex carbohydrate diet
Metabolism 43:1481-1487, 1994
Piatti PM, Monti LD, Magni F, Fermo I, Baruffaldi L, Nasser R, Santambrogio G, Librenti MC, Galli-Kienle M, Pontiroli AE, Pozza G
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Forearm insulin- and non-insulin-mediated glucose uptake and muscle metabolism in man: role of free fatty acids and blood glucose levels.
Metabolism 40: 926-933,1991
Piatti PM, Monti LD, Pacchioni M, Pontiroli AE, Pozza G
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