Paola Cinque

Location:

Department of Infectious Diseases

Languages:

Biography

Dr. Paola Cinque is an infectious disease specialist at the Infectious Diseases Unit of the IRCCS Ospedale San Raffaele Turro, led by Professor Antonella Castagna.

After earning her degree in Medicine and Surgery from the University of Milan in 1987 (with honors) and specializing in Infectious Diseases in 1991 (with top marks), she began her clinical career at the Infectious Diseases Clinic of the L. Sacco Hospital in Milan. She then spent three years at the Department of Virology at the Karolinska Institute in Stockholm, where she studied molecular diagnostic methods for nervous system infections and obtained her PhD in Virology in 1995. In 1994, she joined the Infectious Diseases Division to pursue clinical and research activities.

Dr. Cinque was an Adjunct Professor at the Vita-Salute San Raffaele University (UniSR) from 1999 to 2021, teaching Infectious Diseases courses in both Italian and English (IMDP) and coordinating the latter from 2014 to 2021.

Her clinical focus includes HIV infection and its complications, nervous system infections (such as encephalitis and meningitis), progressive multifocal leukoencephalopathy (PML), opportunistic infections in immunocompromised individuals, herpesvirus infections (including genital herpes and other recurrent forms), sexually transmitted infections, and COVID-19 and its complications.

Dr. Cinque has an extensive background in clinical research, particularly in the fields of nervous system infections, PML, opportunistic infections, and HIV infection. She has received multiple grants from national and international organizations for her work, contributing to the identification of biomarkers for diagnosis and clinical monitoring, as well as understanding disease mechanisms to develop and test new pharmacological approaches. In recent years, she has also initiated research projects exploring the role of physical activity in health and inflammation control. She actively collaborates with various clinical and research institutions, both nationally and internationally, and is involved in drafting guidelines for the management and treatment of HIV infection and opportunistic infections. Dr. Cinque has authored approximately 230 scientific publications in international journals and has an H-index of 56.

Education

University of Milan
Degree in Medicine and Surgery - 1987

University of Milan
Specialization in Infectious Diseases - 1991

Karolinska Institute, Stockholm, Sweden
PhD in Virology - 1995

Do you need an appointment?

Request an appointment

Publications

Latest publications

International HIV-Cognition Working Group. A new approach to cognitive impairment in people with HIV.

Lancet HIV. 2022 Dec;9(12):e815-e817. doi: 10.1016/S2352-3018(22)00267-3

Nightingale S, Cinque P, Joska JA, Price RW, Underwood J

Benefits of a 12 week physical activity programme on muscle and bone health in people living with HIV.

J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1613-1616. doi: 10.1002/jcsm.12824.

Bonato M, Galli L, Bossolasco S, Bertocchi C, Balconi G, Borderi M, Viale P, Pavei G, Merati G, La Torre A, Lazzarin A, Banfi G, Cinque P.

A Mobile Application for Exercise Intervention in People Living with HIV.

Medicine and Science in Sports and Exercise 2020, 52 (2), pp. 425-433 DOI: 10.1249/MSS.0000000000002125

Bonato, M., Turrini, F., De Zan, V., Meloni, A., Plebani, M., Brambilla, E., Giordani, A., Vitobello, C., Caccia, R., Piacentini, M.F., La Torre, A., Lazzarin, A., Merati, G., Galli, L., Cinque, P.

Symptomatic cerebrospinal fluid escape.

AIDS. 2019 Dec 1;33 Suppl 2:S159-S169. doi: 10.1097/QAD.0000000000002266. PMID: 31789816

Mastrangelo A, Turrini F, de Zan V, Caccia R, Gerevini S, Cinque P.

Diagnostic and prognostic value of JC virus DNA in plasma in progressive multifocal leukoencephalopathy.

Clinical Infectious Diseases 2018, 67 (1), pp. 65-72. DOI: 10.1093/cid/ciy030

Ferretti, F., Bestetti, A., Yiannoutsos, C.T., Musick, B.S., Gerevini, S., Passeri, L., Bossolasco, S., Boschini, A., Franciotta, D., Lazzarin, A., Cinque, P.

A pilot study of brisk walking in sedentary combination antiretroviral treatement (cART)- treated patients: Benefit on soluble and cell inflammatory markers.

BMC Infectious Diseases 2017, 17 (1), art. no. 61. DOI: 10.1186/s12879-016-2095-9

Bonato, M., Galli, L., Passeri, L., Longo, V., Pavei, G., Bossolasco, S., Bertocchi, C., Cernuschi, M., Balconi, G., Merati, G., Lazzarin, A., La Torre, A., Cinque, P.

JC polyomavirus mutants escape antibody-mediated neutralization.

Sci Transl Med 2015; 7: 306ra151. DOI: 10.1126/scitranslmed.aab1720

Ray U, Cinque P, Gerevini S, Longo V, Lazzarin A, Schippling S, Martin R, Buck CB, Pastrana DV.

Progressive multifocal leukoencephalopathy (PML) development is associated with mutations in JC virus capsid protein VP1 that change its receptor specificity.

J Infect Dis 2011;204:103-14. DOI: 10.1093/infdis/jir19

Gorelik L, Reid C, Testa M, Brickelmaier M, Bossolasco S, Pazzi A, Bestetti A, Carmillo P, Wilson E, McAuliffe M, Tonkin C, Carulli JP, Lugovskoy A, Lazzarin A, Sunyaev S, Simon K, Cinque P.

Progressive multifocal leukoencephalopathy in HIV-1 infection.

Lancet Infect Dis 2009;9:625-36. Review. DOI: 10.1016/S1473-3099(09)70226-9

Cinque P, Koralnik IJ, Gerevini S, Miro JM, Price RW.

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain.

J Exp Med 2007;204:2899-912. DOI: 10.1084/jem.20071030

Serafini B, Rosicarelli B, Franciotta D, Magliozzi R, Reynolds R, Cinque P, Andreoni L, Trivedi P, Salvetti M, Faggioni A, Aloisi F.

Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication.

AIDS 1998;12:1327-32. DOI: 10.1097/00002030-199811000-00014

Cinque, P., Vago, L., Mengozzi, M., Torri, V., Ceresa, D., Vicenzi, E., Transidico, P., Vagani, A., Sozzani, S., Mantovani, A., Lazzarin, A., Poli, G.

Prognostic significance of JC virus DNA levels in cerebrospinal fluid of patients with HIV-associated progressive multifocal leukoencephalopathy.

Clin Infect Dis 2005;40:738-44. DOI: 10.1086/427698

Bossolasco S, Calori G, Moretti F, Boschini A, Bertelli D, Mena M, Gerevini S, Bestetti A, Pedale R, Sala S, Sala S, Lazzarin A, Cinque P.

Diagnosis of central nervous system complications in HIV-infected patients: Cerebrospinal fluid analysis by the polymerase chain reaction.

AIDS 1997;11:1-17. DOI: 10.1097/00002030-199701000-00003

Cinque, P., Scarpellini, P., Vago, L., Linde, A., Lazzarin, A.

Polymerase chain reaction on cerebrospinal fluid for diagnosis of virus-associated opportunistic diseases of the central nervous system in HIV-infected patients.

AIDS 1996;10:951-8. DOI: 10.1097/00002030-199610090-00004

Cinque, P., Vago, L., Dahl, H., Brytting, M., Terreni, M.R., Fornara, C., Racca, S., Castagna, A., Monforte, A.D., Wahren, B., Lazzarin, A., Linde, A.

The role of laboratory investigation in the diagnosis and management of patients with suspected herpes simplex encephalitis: A consensus report.

J Neurol Neurosurg Psychiatry 1996;61:339-45. DOI: 10.1136/jnnp.61.4.339

Cinque, P., Cleator, G.M., Weber, T., Monteyne, P., Sindic, C.J., Van Loon, A.M.

Epstein-Barr virus DNA in cerebrospinal fluid from patients with AIDS-related primary lymphoma of the central nervous system.

Lancet 1993;342: 398-401. DOI: 10.1016/0140-6736(93)92814-A

Cinque, P., Brytting, M., Vago, L., Castagna, A., Parravicini, C., Zanchetta, N., D'Arminio Monforte, A., Wahren, B., Lazzarin, A., Linde, A.

Do you need an appointment?

Request an appointment