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Gruppo San Donato offers advanced care in rheumatology, specializing in the diagnosis and treatment of musculoskeletal and autoimmune conditions. The center provides comprehensive care for a broad spectrum of rheumatological diseases, including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, lupus, vasculitis, and osteoporosis.

To ensure effective treatment, advanced diagnostic and therapeutic techniques such as musculoskeletal ultrasound, joint injections, and video capillaroscopy are incorporated. These methods are seamlessly integrated into the care process to provide patients with the most accurate assessments and personalized treatment plans.

In addition to clinical care, the expert team at Gruppo San Donato plays an active role in shaping national and international rheumatology guidelines. This commitment to research and innovation helps to ensure that patients receive the latest advancements in rheumatological care

The research activities of the Department of Allergy, Immunology, Rheumatology and Rare Diseases at San Raffaele Hospital focus on the pathogenesis of rheumatological and immune-mediated diseases, allergological conditions, and rare diseases of the immune system.

The main research areas include:

• Study of the pathogenesis of rare diseases, with particular attention to diseases of the immune system;
• Investigation of the molecular mechanisms underlying Erdheim-Chester disease and identification of new pharmacological intervention possibilities for its treatment;
• Study of molecular mechanisms and therapeutic strategies for IgG4-related disease;
• Development of innovative and experimental therapies for the treatment of immune-mediated diseases;
• Research into potential microbial agents involved in the genesis of immune-mediated inflammatory diseases;
• Identification of relevant pathogenic factors associated with the prognosis of patients with systemic vasculitis;
• Definition of the primary modes of action of biological drugs (cytokines and anti-cytokines, monoclonal antibodies) and their use in combination with traditional background therapies;
• Molecular diagnostics for respiratory and food allergies (ISAC);
• Basophil activation tests with drugs, food, and food additives;
• Study of immunological mechanisms underlying inflammation in chronic polypoid rhinosinusitis.